2,2',6-Tribromobisphenol A

2,2',6-Tribromobisphenol A (Tri-BBPA) is a degradation product of the flame retardant tetrabromobisphenol A and an environmental contaminant.¹ It is an inhibitor of 12-lipoxygenase (12-LO) and 15-LO (IC₅₀s = 7 and 5 µM, respectively, for the human enzymes).² Tri-BBPA (60 µM) induces apoptosis and cell cycle arrest at the G₀/G₁ phase in primary human embryonic stem cells (ESCs).³ It decreases serum levels of total protein, albumin, γ-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH), creatine kinase (CK), and urea, increases serum levels of acetylcholinesterase (AChE), and disrupts hepatic metabolism of tryptophan (Item No. 29600) in mice when administered at a dose of 200 mg/kg per day for 14 days.⁴ Tri-BBPA has been found in industrial soil samples and human breast milk.^1,5

WARNING This product is not for human or veterinary use.

1. Liu, A., Shi, J., Qu, G., et al. Identification of emerging brominated chemicals as the transformation products of tetrabromobisphenol A (TBBPA) derivatives in soil. Environ. Sci. Technol. 51(10), 5434-5444 (2017).

2. Segraves, E.N., Shah, R.R., Segraves, N.L., et al. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J. Med. Chem. 47(16), 4060-4065 (2004).

3. Yang, Y., He, S., Qi, Z., et al. Proliferation toxicity and mechanism of novel mixed bromine/chlorine transformation products of tetrabromobisphenol A on human embryonic stem cell. J. Hazard. Mater. 449, 131050 (2023).

4. Kuang, H.X., Dong, C.Y., Yan, L., et al. Exposure to synthesized tribromobisphenol A and critical effects: Metabolic pathways, disease signature, and benchmark dose derivation. Sci. Total Environ. 932, 173117 (2024).

5. Nakao, T.A., Akiyama, E., Kakutani, H., et al. Levels of tetrabromobisphenol A, tribromobisphenol A, dibromobisphenol A, monobromobisphenol A, and bisphenol a in Japanese breast milk. Chem. Res. Toxicol. 28(4), 722-728 (2015).