A potent CB1 receptor agonist
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S-2 Methanandamide

Item No. 90076

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2S-hydroxypropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number
157182-48-4
Synonyms
  • (S)-(+)-Arachidonyl-2'-Hydroxy-1'-Propylamide
Molecular Formula
C23H39NO2
Formula Weight
361.6
Purity
≥98%
Formulation
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >10 mg/mlDMSO: >30 mg/mlEthanol: >100 mg/mlEthanol:PBS (1:2): 8.5 mg/mlPBS (pH 7.2): <100 µg/ml
SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(C)O
InChi Code
InChI=1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(26)24-21-22(2)25/h7-8,10-11,13-14,16-17,22,25H,3-6,9,12,15,18-21H2,1-2H3,(H,24,26)/b8-7-,11-10-,14-13-,17-16-/t22-/m0/s1
InChi Key
HTNMZCWZEMNFCR-AQNSPSBUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $59

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    10 mg

    $106

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    25 mg

    $236

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    Product Description

    S-2 methanandamide is the second most potent CB1 receptor agonist in the methanandamide series. It has a Ki value of 26 nM for the CB1 receptor.1 S-2 methanandamide is also less prone to FAAH inactivation and inhibits the murine vas deferens twitch response with an IC50 value of 47 nM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abadji, V., Lin, S., Taha, G., et al. (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J. Med. Chem. 37(12), 1889-1893 (1994).