Pricing updated 2019-07-17. Prices are subject to change without notice.
(−)-CP 55,940 is a potent and non-selective cannabinoid (CB) receptor agonist with Ki values of 0.5 to 5 and 0.69 to 2.8 nM for CB1 and CB2 receptors, respectively.1 It is more potent than Δ9-THC (Item Nos. 12068 | ISO60157) in both behavioral tests and in receptor binding assays.2 In vivo, (−)-CP 55,940 administered intraperitoneally (0.3-3 mg/kg) or as an aerosol (0.72-72 mg/ml), suppresses locomotor activity, increases tail flick latency in a hot plate test for analgesia, and decreases body temperature in mice in a dose-dependent manner.3 Subchronic administration of (−)-CP 55,940 (0.03 mg/kg) also reduces body weight loss and running wheel activity in a rat model of anorexia nervosa.4
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1. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8), 635-664 (1999).
2. Wiley, J.L., Barrett, R.L., Lowe, J., et al. Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats Neuropharmacology 34(6), 669-676 (1995).
Lefever, T.W., Marusich, J.A., Thomas, B.F., et al. Vaping synthetic cannabinoids: A novel preclinical model of E-
Scherma, M., Satta, V., Collu, R., et al. Cannabinoid CB1 /CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-