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(−)-CP 55,940

Item № 90084
CAS № 83002-04-4
Purity ≥98%
product image
                (CAS 83002-04-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $126.00 0.00
     10 mg $196.00 0.00
     25 mg $455.00 0.00

Pricing updated 2019-05-26. Prices are subject to change without notice.

Description

(−)-CP 55,940 is a potent and non-selective cannabinoid (CB) receptor agonist with Ki values of 0.5 to 5 and 0.69 to 2.8 nM for CB1 and CB2 receptors, respectively.1 It is more potent than Δ9-THC (Item Nos. 12068 | ISO60157) in both behavioral tests and in receptor binding assays.2 In vivo, (−)-CP 55,940 administered intraperitoneally (0.3-3 mg/kg) or as an aerosol (0.72-72 mg/ml), suppresses locomotor activity, increases tail flick latency in a hot plate test for analgesia, and decreases body temperature in mice in a dose-dependent manner.3 Subchronic administration of (−)-CP 55,940 (0.03 mg/kg) also reduces body weight loss and running wheel activity in a rat model of anorexia nervosa.4

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Technical Information
Formal Name
5-(1,1-dimethylheptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-phenol
CAS Number
83002-04-4
Molecular Formula
C24H40O3
Formula Weight
376.6
Purity
≥98%
Formulation
A solution in methanol
λmax
219, 277 nm
SMILES
CCCCCCC(C)(C)c1ccc(c(O)c1)[C@@H]1C[C@H](O)CCC1CCCO
InChI Code
InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
InChI Key
YNZFFALZMRAPHQ-SYYKKAFVSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8), 635-664 (1999).

2. Wiley, J.L., Barrett, R.L., Lowe, J., et al. Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats Neuropharmacology 34(6), 669-676 (1995).

3. Lefever, T.W., Marusich, J.A., Thomas, B.F., et al. Vaping synthetic cannabinoids: A novel preclinical model of E-cigarette use in mice Subst. Abuse 11, (2017).

4. Scherma, M., Satta, V., Collu, R., et al. Cannabinoid CB1 /CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia Br. J. Pharmacol. 174(16), 2682-2695 (2017).

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