A nonspecific inhibitor of cyclooxygenases and lipoxygenases
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5,8,11,14-Eicosatetraynoic Acid

Item No. 90120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1191-85-1
Synonyms
  • ETYA
  • FA 20:8
Molecular Formula
C20H24O2
Formula Weight
296.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
SMILES
CCCCCC#CCC#CCC#CCC#CCCCC(O)=O
InChi Code
InChI=1S/C20H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14,17-19H2,1H3,(H,21,22)
InChi Key
MGLDCXPLYOWQRP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $178

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    25 mg

    $347

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    50 mg

    $644

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    Product Description

    5,8,11,14-Eicosatetraynoic Acid (ETYA) is a nonspecific inhibitor of cyclooxygenases and lipoxygenases.1 ETYA inhibits human platelet 12-LO and COX-1 with IC50 values of 4 µM and 8 µM, respectively.1 ETYA is a PPAR ligand which activates PPARα and PPARγ chimeras at concentrations of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hammarström, S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim. Biophys. Acta 487(3), 517-519 (1977).

    2. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83(5), 813-819 (1995).

    Product Citations

    Caires, R., Sierra-Valdez, F.J., Millet, J.R.M., et al. Omega-3 fatty acids modulate TRPV4 function through plasma membrane remodeling. Cell Reports 21, 245-258 (2017).