A nonselective inhibitor of lipoxygenases
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5,8,11-Eicosatriynoic Acid

Item No. 90200

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,11-eicosatriynoic acid
CAS Number
13488-22-7
Synonyms
  • 5,8,11-ETI
  • FA 20:6
Molecular Formula
C20H28O2
Formula Weight
300.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: 1 mg/mlDMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:1): 500 µg/mlPBS pH 7.2: <50 µg/ml
SMILES
CCCCCCCCCCCCCCCCCCCC(=O)O
InChi Code
InChI=1S/C20H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-8,11,14,17-19H2,1H3,(H,21,22)
InChi Key
OWYNLPMPYBYKJP-UHFFFAOYSA-N
Side Chain Carbon Sum
20:3
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM.1 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM.2 At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases (ID50 = 340 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hammarström, S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim. Biophys. Acta 487(3), 517-519 (1977).

    2. Örning, L., and Hammarström, S. Inhibition of leukotriene C and leukotriene D biosynthesis. The Journal of Biological Chemisty 255(17), 8023-8026 (1980).