A GPR40 agonist and GPR120 partial agonist
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MEDICA 16

Item No. 90290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3,14,14-tetramethylhexadecanedioic acid
CAS Number
87272-20-6
Synonyms
  • FA 20:0;O2
Molecular Formula
C20H38O4
Formula Weight
342.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid)DMF: >100 mg/ml (from Oleic Acid)DMSO: >100 mg/ml (from Oleic Acid)Ethanol: >100 mg/ml (from Oleic Acid)PBS pH 7.2: <100 µg/ml (from Oleic Acid)
SMILES
OC(=O)CC(C)(C)CCCCCCCCCCC(C)(C)CC(=O)O
InChi Code
InChI=1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
InChi Key
HYSMCRNFENOHJH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    50 mg

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    Product Description

    MEDICA 16 is a G protein-coupled receptor 40 (GPR40) agonist and GPR120 partial agonist.1 MEDICA 16 induces intracellular calcium mobilization in cells expressing GPR40 or GPR120 in a concentration-dependent manner. It induces ERK activation in cells expressing GPR40 or GPR120 when used at a concentration of 100 µM. MEDICA 16 also inhibits ATP citrate lyase (Kis = 40 and 200 µM for the oxidized and reduced enzyme, respectively).2 Chronic dietary administration of MEDICA 16 (0.25% w/w) decreases liver acetyl-CoA carboxylase (ACC) and AMP-activated protein kinase (AMPK) levels in a model of insulin resistance using JCR:LA-cp rats, which lack functioning leptin receptors.3 MEDICA 16 (0.25% w/w in the diet) reduces plasma insulin levels, decreases fasting plasma triacylglycerol levels, and delays the onset of hyperinsulinemia in JCR:LA-cp rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hara, T., Hirasawa, A., Sun, Q., et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 380(3), 247-255 (2009).

    2. Wells, T.N.C., and Saxty, B.A. Redox control of catalysis in ATP-citrate lyase from rat liver. Eur. J. Biochem. 204(1), 249-255 (1992).

    3. Atkinson, L.L., Kelly, S.E., Russell, J.C., et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats. Diabetes 51(5), 1548-1555 (2002).

    4. Russell, J.C., Shillabeer, G., Bar-Tana, J., et al. Development of insulin resistance in the JCR:LA-cp rat: Role of triacylglycerols and effects of MEDICA 16. Diabetes 47(5), 770-778 (1998).