An inhibitor of both COX and lipoxygenase
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9,12-Octadecadiynoic Acid

Item No. 90400

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
octadeca-9,12-diynoic acid
CAS Number
2012-14-8
Synonyms
  • FA 18:4
  • Ro 3-1314
Molecular Formula
C18H28O2
Formula Weight
276.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid)DMF: >100 mg/ml (from Oleic Acid)DMSO: >100 mg/ml (from Oleic Acid)Ethanol: >100 mg/ml (from Oleic Acid)PBS pH 7.2: <100 µg/ml (from Oleic Acid)
SMILES
CCCCCC#CCC#CCCCCCCCC(O)=O
InChi Code
InChI=1S/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-5,8,11-17H2,1H3,(H,19,20)
InChi Key
KDYILQLPKVZDGB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    9,12-Octadecadiynoic acid is an inhibitor of both COX and lipoxygenase.1,2 9,12-octadecadiynoic acid inhibits ram seminal vesicle COX with a Ki of 0.6 µM.1 It is a more effective inhibitor of COX-1 than of 15-LO, inhibiting 95% and 68%, respectively, of these enzymatic activities when used at a concentration of 48 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vanderhoek, J.Y., and Lands, W.E.M. Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim. Biophys. Acta 296, 374-381 (1973).

    2. Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim. Biophys. Acta 280, 343-347 (1972).