CRO & CDMO SERVICES

Bioanalysis
& Assay Development

  • Sample Analysis & Screening
  • Lipidomics
  • Immunopeptidome Profiling
  • Cellular Metabolism
  • Protein & Antibody Production
  • High-Content Analysis (HCA)
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Medicinal Chemistry
& Structural Biology

  • Computer-Aided Drug Design
  • Structure-Based Drug Design
  • SAR Studies
  • Parallel Medicinal Chemistry
  • Biophysical Characterization
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Analytical
Chemistry

  • Targeted & Untargeted Lipid Analysis
  • LC-MS & GC-MS Method Development
  • Pharmacokinetic Sample Analysis
  • NMR & MS Structural Characterization
  • In Vitro DMPK
  • Physicochemical Properties Testing
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Chemical
Synthesis

  • Lipid & Small Molecule Synthesis
  • Bioconjugate Synthesis
  • Stable Isotopic Labeling
  • Natural Product Isolation & Biocatalysis
  • Lipid Nanoparticle Development
  • Synthetic Route Optimization & Scale-Up
  • Pre-GMP Process Development
Learn More

Our Services

Cayman is a US-based CRO and CDMO providing chemistry and biology services to the global pharmaceutical, biotechnology, and academic research markets. Our diverse suite of services leverages a team of more than 170 highly skilled scientists with expertise in medicinal chemistry, structural biology, bioanalysis, custom assay development, complex multi-step organic synthesis, analytical chemistry, GMP API manufacturing, and more. We offer a personalized, flexible approach that enables our clients to address research questions from basic research to drug discovery and development.

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Our services are also available through these online marketplaces:

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Integrated Drug Discovery

With our wide range of chemistry and biology services, Cayman is perfectly positioned to provide integrated, multidisciplinary development and preclinical drug discovery services to accelerate your journey from target to clinic. Our drug discovery services are powered by expertise in computational chemistry, compound screening, medicinal chemistry, chemical synthesis, structural biology, and GMP API manufacturing. Additional experts in assay development, cellular metabolism, immunology, and cell and molecular biology can develop custom assays and model systems to test your compounds in the most relevant contexts. Use the links below to explore how our services can be used in the context of small molecule therapeutic discovery:

Learn how Cayman's integrated drug discovery services accelerated the discovery and design of novel heterocyclic inhibitors from hit identification through lead optimization in less than 10 months.

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Our drug discovery services can be used for small and large molecule therapeutics, biologics, and neutralizing antibodies, as well as biomarker and companion diagnostic development. Additional specializations that can be incorporated into your drug discovery program include:

Contact us to discuss your drug discovery needs and how Cayman can customize a program that fits your unique project requirements.

Why Cayman?

Maintain complete control of your study with phase-based, flexible project design.

Consult with our cross-functional team of scientists with expertise in diverse research areas and technical skill sets.

Access our state-of-the-art laboratories with dedicated resources to support your project needs.

Read What Our Clients Are Saying

"My biotech startup company was operating with limited resources and needed a way to prioritize the synthesis of one or two members of a family of nitric oxide donors on the possibility that some of these compounds might have antiviral properties against SARS-CoV-2. I used the medicinal chemistry services of Cayman Chemical to do the in silico work needed to come up with two hits that later proved to have antiviral properties in vitro. This identified intellectual property and justified a much broader drug development program."
John F. Schmedtje Jr., MD
President and CEO
Coeurative, Inc.
"We have worked with the Bioanalysis group at Cayman Chemical on multiple projects.  The scientists are outstanding at executing on established protocols as well as troubleshooting projects that are in an optimization/discovery stage.  There is a high degree of communication throughout the process which we have found vital when projects hit a hurdle and we need to pivot from the original plan.  They are a trusted resource for cellular based assays, especially flow cytometry, and consistently provide excellent guidance and data for these types of projects."
Amy Hopkin
Principal Scientist
AVITA Medical
"I’ve worked with Cayman on several occasions. Most recently, they developed a novel UPLC methodology for quantification of an eicosanoid that had been particularly difficult to quantify with ELISA. Communication was prompt and professional, and the work was completed on time as promised. I’d recommend talking with these people before engaging in any project involving analysis of bioactive lipids. You might be surprised what they can do for you!"
Director, Gene Therapy Program
Allegheny General Hospital
"The Cellular Metabolism group helped us establish an in vitro assay to screen compounds of interest for potential activity at a certain class of enzyme. We were interested in understanding if there were any significant differences between compounds derived from different sources. Cayman demonstrated excellent technical competence, particularly with regards to helping us understand all aspects of the experimental data. They were also able to design specific experiments to probe the mechanism of interaction between the compounds and the enzyme, which were useful for compound de-risking/safety."
Ashley Davies
Scientist
British American Tobacco
"Cayman Chemical helped us to significantly advance our project, even while our laboratories were shut down due to COVID-19. We were extremely pleased that Cayman Chemical completed challenging, multi-step, multi-gram syntheses of multiple intermediates that we were able to diversify to various final products. We have since used one of these compounds as a substrate for high-throughput screening campaigns here at Purdue University in our search for potential enzyme modulators."
Daniel Beck
Medicinal Chemist
Institute for Drug Discovery, Purdue University
"Cayman was enormously helpful to us with our program to discover and develop new small molecule modulators of ligand/receptor interactions. We made extensive use of its medicinal chemistry, assay development, structural biology, and analytical chemistry services resulting in the successful identification and characterization of several promising lead candidates. In addition to its technical proficiency, Cayman provided expert, highly-collaborative and critical guidance to our program."
Seth Finklestein, MD
CEO
Recovery Therapeutics, Inc.
"The technical staff at Cayman is highly trained and has diligently applied themselves to our specific projects. The breadth of the staff competencies has allowed us to pursue multiple technical paths in reaching our development goals within the timeline and cost anticipated. Overall, the team at Cayman Chemical has been an excellent resource and has exceeded our expectations."
Chief Scientific Officer
Progenity, Inc.
"The [Cayman] team has overcome a number of structural hurdles on hard-to-express proteins, identified work-arounds when challenges were encountered, and always exceeded timelines and expectations. In the work we have done, we have elucidated novel interactions and helped to understand the interface between chemistry and biology. Within our work, there is always a high degree of communication and complete transparency about the work from start to finish."
Director of Discovery Research
Karos Pharmaceuticals

Our Partners

Cayman partners with industry leaders to expand our capabilities and give our clients access to additional cutting-edge resources:

What Can We Help You Discover?

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