Lipid Nanoparticle Development

Lipid nanoparticles (LNPs) are delivering new possibilities in nucleic acid therapies, yet navigating LNP development is highly complex and presents many challenges.

With expertise in lipid chemistry and synthesis, bioanalysis, and cell biology, our team helps demystify LNP formulation, offering the right support at every step to guide your vision to completion.

Our Services

Custom Lipid Synthesis

LNP FORMULATION & CHARACTERIZATION

LNP ANALYSIS & SCREENING

Custom Lipid Synthesis

We offer custom synthesis of high-purity LNP components including:

Fixed & ionizable cationic lipids
Helper lipids
Sterol lipids
PEGylated lipids
Custom & proprietary lipids
Functionalized & bioconjugated lipids for cell/tissue targeting

Our state-of-the-art US-based facilities can accommodate scalable lipid synthesis for research grade and CGMP lipids.

Lipid Synthesis & CGMP Manufacturing

Synthetic feasibility & route scouting
Process development & optimization
Manufacturing & scale-up
Fully equipped analytical facilities for validation

LNP Formulation & Characterization

Our scientists will help you determine the optimal LNP composition and experimental design for your cargo and tissue or cell type of interest. We prepare LNPs using microfluidic mixing and perform comprehensive particle characterization and stability testing.

Lipid component selection

Choose from ready-made lipids or custom lipid synthesis

Cargo selection

Choose from reporter mRNAs or custom cargoes

LNP targeting strategies
Experimental design

Tunable microfluidic mixing parameters
Variable lipid ratios & flow rates
Screening or bulk preparations
Scalable volumes up to 200 ml

LNP & payload concentration
Particle size
Polydispersity index
Apparent pK_a
Aggregation
Encapsulation efficiency
Stability

LNP Analysis & Screening

Cayman provides expert bioanalytical services for the evaluation and optimization of LNPs.

We offer multiple assay formats to measure reporter and therapeutic payload delivery and expression, effects on cell viability, and downstream biological effects:

Cell-based assays
Reporter assays
Enzyme activity assays
High-content imaging
Luminescent & fluorometric readouts
Flow cytometry
Mass spectrometry
Immunoassays
ELISpot
Immunophenotyping

Choose from ready-made assays or explore our custom assay development and high-throughput options. Our bioanalysis, screening, and assay development services are supported by expertise across multiple therapeutic and research areas.

Pricing

Pricing for our LNP development services varies based on each project’s unique specifications. Submit the “Contact Us” form for project-specific pricing.