An LSD1 inhibitor
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GSK-LSD1 (hydrochloride)

Item No. 16439

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)Epigenetic Chemical Probe Guide (PDF)
Technical Information
Formal Name
rel-N-[(1R,2S)-2-phenylcyclopropyl]-4-piperidinamine, dihydrochloride
CAS Number
2102933-95-7
Molecular Formula
C14H20N2 • 2HCl
Formula Weight
289.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 25 mg/mlEthanol: 0.1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
211 nm
SMILES
[C@H]1(C2=CC=CC=C2)[C@H](NC3CCNCC3)C1.Cl.Cl
InChi Code
InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1
InChi Key
PJFZOGMSPBHPNS-WICJZZOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    GSK-LSD1 is an irreversible, mechanism-based inhibitor of LSD1 (IC50 = 16 nM) that is >1,000-fold selective over the closely related FAD-utilizing enzymes LSD2, MAO-A, and MAO-B.1 GSK-LSD1 induces gene expression changes in various cancer cell lines, inhibiting their proliferation (EC50s <5 nM).1 See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  Epigenetics probes collection. (2014).

    Product Citations

    Bailey, C.P., Figueroa, M., Gangadharan, A., et al. Scaffolding LSD1 inhibitors impair NK cell metabolism and cytotoxic function through depletion of glutathione. Front. Immunol. 11, 2196 (2020).