​ω-NBD sphingosine is a biologically active derivative of sphingosine that is tagged with a fluorescent nitrobenzoxadiazole (NBD) group. Sphingosine (d18:1) (Cayman Item No. 10007907) is an important precursor to sphingosine-1-phosphate. The two enzymes that are responsible for this process are the sphingosine kinases SPHK1 and SPHK2. The fluorescently tagged ω-NBD sphingosine (Cayman Item No. 25348) allows researchers to monitor the activity of these kinase enzymes in real time. ω-NBD sphingosine has been previously described in literature, and the former method of synthesis was thirteen steps long. We have developed a more efficient method of synthesis that is only six steps long. 

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To cite this poster: Hyder, S. and Uzieblo, A. A new, efficient synthesis of ω-NBD sphingosine. Poster presented at: Bioactive Lipids in Cancer, Inflammation, and Related Diseases 16^th International Conference; October 20-23, 2019; St. Petersburg, FL.