Updated March 2025

Ferroptosis is a type of cell death driven by iron-dependent phospholipid peroxidation and regulated by multiple cellular pathways, including redox homeostasis, iron handling, and mitochondrial activity, that has been associated with various pathophysiologies. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase or the ferroptosis suppressor protein, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells. This poster summarizes the current understanding of the mechanisms of induction and suppression underlying this cell death process.

Read the article Ferroptosis: Detecting a new form of cell death and download the Ferroptosis Research Tools brochure for additional information on known inducers and suppressors of this cell death pathway.