Literature & Media

Modulation of ENPP1 Activity and 2´3´-cGAMP Degradation in Ovarian Cancer Cell Lines via Loadable Preformed Lipid Nanoparticles

Webinars

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) suppresses innate immunity and promote tumor progression and metastasis in the tumor microenvironment. ENPP1 inhibits STING signaling by hydrolyzing the degradation of 2',3'-cGAMP, blunting induction of the type 1 interferon response and antitumor immunity.

Listen as David Taylor, Ph.D., a scientist in Cayman's Assay Research & Development group, modulates ENPP1 expression and STING activation in ovarian cancer cell lines and macrophages with LipidLaunch™ Loadable LNPs and explores the contribution of ovarian cancer cell-derived extracellular vesicles in the tumor microenvironment.

Presented as part of the 2024 Tumor Microenvironment and Therapy Symposium at The University of Michigan.

Read the Webinar Highlights for a quick overview of the key takeaways. 

Do you have a question or comment for the presenter? Let us know.

Learn more about LipidLaunch™ LNPs and reagent kits.

Cayman ChemicalCayman ChemicalCayman Chemical

Receive Our News & Literature Directly to Your Inbox!

Log in or register to subscribe to our email list. You will receive emails packed with new products and content that match your research interests. We only email once a week and you can unsubscribe at any time.