Cayman's LipidLaunch™ research-ready LNPs and reagent kits support the entire LNP research and development process, offering tailored solutions from discovery to bioanalysis.

LipidLaunch™ Selection Guide

Use this chart to find the right LipidLaunch™ product for your research.

	Preloaded LNPs	Loadable LNPs	LNP Exploration Kits	LNP Uptake Kits
	Preformulated LNPs containing reporter gene mRNA, ideal for initial pilot or proof-of-concept experiments.	Cargo-ready, preformulated LNPs that allow researchers to deliver their chosen RNA cargo.	Complete kits with individually packaged reagents for creating customized LNPs without specialized equipment.	Built on the Exploration Kit format, these kits include a fluorescently labeled lipid for visualizing LNP cellular uptake.
Ideal for LNP Screening
Features Reporter Readout
Custom Cargo Compatible
Customizable LNP Formulation
Hands-On Time Required
Suggested Use	First choice for pilot studies and novice researchers	Preferred option for custom cargo and maximum ease-of-use	Top choice for preparing LNPs with custom cargo and formulation	Ideal for visualizing cellular uptake with custom LNPs
Available Formats	View Online	View Online	View Online	View Online

Featured LipidLaunch™ Collection: SM-102

SM-102 was brought to the forefront of LNPs during the COVID-19 pandemic. It is one of the components of the mRNA-1273 COVID-19 vaccine. Cayman was the first company to offer research-grade SM-102 during the COVID-19 pandemic. Now, we are pleased to offer a complete lineup of SM-102-based LipidLaunch™ research tools.

LipidLaunch™ Research Tools Simplify Discovery Across the LNP Pipeline

LipidLaunch™ Research Tools aim to simplify LNP research by providing accessible and cost-effective solutions for researchers at all stages of their work. These research-ready LNPs and reagent kits utilize lipid formulations of broad and current interest, such as those used in mRNA-based vaccines or cell and gene therapies. Available in various formats, they offer researchers flexibility in cargo selection and LNP formulation.

Designed with researcher accessibility in mind, LipidLaunch™ research tools require minimal hands-on time and expertise. Preloaded and Loadable LNPs eliminate the need for expensive and complex mixing steps, ensuring ease of use. The Exploration and Uptake Kits allow for LNP preparation using simple hand mixing techniques or, if available, microfluidic mixers.

Next Steps

Explore Different Lipids in LNP Formulations

After initial experiments, many researchers explore custom LNPs with varying lipid identity and composition. Cayman offers an extensive and continuously expanding catalog of ready-made lipids that can be used to formulate LNPs.

Custom design and synthesis of novel lipids is also available. 

Simplify LNP Screening and Optimization

Streamline selection of candidate ionizable lipids and benefit from ready-made helper lipid sets and formulation buffers to simplify LNP screening and optimization.

A Ready-to-Use Premixed Buffer for LNP Formulation

The LipidLaunch™ LNP Formulation Buffer is an acidic aqueous buffer designed to optimally encapsulate nucleic acid cargo within LNPs. It consists of an RNase-free solution of 50 mM sodium acetate at pH 4.5. The LipidLaunch™ LNP Formulation Buffer can be used with any selected lipid mixture, including LipidLaunch™ Exploration and Uptake Kits as well as LipidLaunch™ Ionizable Lipid LNP Screening and Helper Lipid Sets.

Measure the LNP Apparent pK_a

The acid dissociation constant (pK_a) is the pH at which the ionized and nonionized forms of an ionizable lipid exist in equal concentrations. pK_a impacts the LNP encapsulation efficiency, efficacy, delivery, and toxicity and is an important parameter in LNP characterization.

Consider Cayman's LNP Development Services

Our interdisciplinary team of scientists has expertise in lipid chemistry and custom synthesis, cell and molecular biology, assay development, immunology, and more to help customize an LNP development program to meet your project goals.

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Cayman Helps Make LNP Research Possible

Cayman Chemical has been supplying high-purity lipids to the scientific community for over 40 years, and our industry-leading expertise in lipid chemistry, synthesis, and purification is supported by state-of-the-art analytical equipment.

We are committed to offering an unprecedented portfolio of LNP research tools. We offer an impressive collection of ready-to-use lipids for LNPs and research-ready LNPs to screen different LNP compositions along with in-house lipid synthesis, screening, and LNP formulation services.

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