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Cayman Compound Libraries

Article from 2021-06-18

Updated March 2025

Small molecule screening libraries for cell biology, drug discovery, and drug identification

Cayman offers a unique set of compound libraries, rich in biologically active molecules, useful for screening and hit-seeking for diverse therapeutic targets. The content of each library is carefully selected from the large collection of small molecules in the Cayman catalog. Each panel is competitively priced with Cayman’s mission in mind to provide affordable, high-quality compounds to help make research possible.

Advantages of Cayman Compound Libraries

Careful Curation

Each panel offers a curated set of compounds focused to the stated purpose of the library with balanced representation across targets when applicable. Our knowledgeable scientists search for highly active, cell-permeable compounds in peer-reviewed literature and within databases such as IUPHAR and the Chemical Probes Portal. Each compound selected for the library meets the solubility, potency, selectivity, and activity criteria established for target validation and early-stage drug discovery. Panels are routinely re-evaluated to include new catalog introductions as the research evolves.

Competitive Pricing

Our curation process allows us to keep our prices low. Many other companies offer compound libraries in the thousands of compounds, with a price tag to match. Cayman's highly focused screening libraries are expertly edited to eliminate redundancies and hit the maximum number of meaningful cellular targets with the minimum number of compounds. This concise design expedites your screening efforts, allowing you to carry on with your research quickly.

Convenient Format

These compounds are prepared in an anhydrous environment and packaged in a 96-well Matrix™ tube rack format as 0.1-10 mM stock solutions in 100% DMSO (unless otherwise indicated) according to industry standards for high-throughput screening. Each library comes with full documentation, including plate maps, targets (when applicable), and references to individual product pages that share full structural and biological information.

Hit Compound Availability

Individual compounds are available for purchase when follow-up experiments are warranted.

Library Customization

Library compilations can be customized to your specifications. Ask our in-house chemists to synthesize novel, drug-like, and/or lead-like screening compounds or choose from our large selection of small molecule inhibitors. Our experts can help you to create a focused group of compounds using the solvent formulation that works best for your application.

Choose from Multiple Screening Panels

Plates come preloaded with a diverse range of compounds. Browse the libraries below and visit the links to download a full list of targets (where applicable) and a map of contents of each well.

Anti-Inflammatory Agents

~235 compounds

Contents include:

Pro-inflammatory cytokine production inhibitors
Macrophage and T cell activation inhibitors
Cytokine storm receptor signaling inhibitors
NLRP3 inflammasome inhibitors
NF-κB signaling inhibitors
Canonical and non-canonical inflammatory kinase signaling pathway inhibitors
Corticosteroids and glucocorticoids
COX-1/-2, 5-LO, mPGES-1, cPLA₂, and sEH inhibitors
NETosis, coagulation, and platelet aggregation-related enzyme and receptor modulators

Antivirals

>410 compounds

Targets include HIV, HBV, HCV, influenza, HSV, coronaviruses, as well as malaria.

Contents include:

HIV reverse transcriptase, protease, and integrase inhibitors
RNA-dependent RNA polymerase inhibitors
HCV nonstructural protein inhibitors

Autophagy

>150 compounds

Contents include:

mTOR, PI3K, LRRK2, and Aurora kinase inhibitors
HDAC inhibitors
Protease inhibitors
Calcium channel blockers
p53 and AMPK modulators
Vps34 inhibitors

Cell Death

~152 compounds

Contents include inducers and inhibitors of multiple cell death pathways:

Apoptosis
Autophagy-dependent cell death
Lysosome-dependent cell death
Entotic cell death
Ferroptosis
Necroptosis
NETosis
Oxeiptosis
Parthanatos
Pyroptosis

Cellular Metabolism

~160 compounds

Contents include modulators of:

Glycolysis
Pentose phosphate pathway
Citric acid cycle
Nucleotide and lipid metabolism
Oxidative phosphorylation
Redox homeostasis

Epigenetic Modulators

>140 compounds

Contents include modulators of:

Methyltransferases
Demethylases
Histone acetyltransferases
Histone deacetylases
Acetylated histone binding proteins

FDA-Approved Drugs

~875 compounds

Contents include:

Antidiabetic drugs
Antiseizure drugs
Antipsychotics
Antibiotics
Antiviral agents
Non-steroidal anti-inflammatory drugs (NSAIDs)
Chemotherapeutics

An Off-Patent Drug Screening Library containing ~607 FDA-approved compounds that are no longer covered under composition-of-matter patents in the United States is also available.

Immuno-Oncology Target Modulators

>90 compounds

Contents include:

Adenosine agonists and antagonists
CCR agonists and antagonists
CXCR agonists and antagonists
TLR agonists and antagonists
BTK inhibitors
PI3K inhibitors
VEGFR inhibitors
B-RAF inhibitors
PD-1/PD-L1 interaction inhibitors
HDAC inhibitors

Kinases

~160 compounds

Targets include:

ROCK
Activin-like kinase (ALK)
GSK3
PKC
PDGFR
VEGFR
Src
MAPK
CDK
PI3K inhibitors

A Comprehensive Kinase Screening Library with greater coverage of individual kinases, kinase isoforms and mutants, and kinase families is also available containing >850 kinase inhibitors.

Microbiome Metabolites

~140 compounds

Contents include a variety of microbiome metabolites such as:

Indole-3-propionic acid
L-Kynurenine
Spermidine
Ellagic acid
Kaempferol
Quinine

Natural Products

~1,640 compounds

Contents include a wide range of natural products, including:

Paclitaxel
Digitoxin
Artemisinin
Caffeine
Ginsenosides
Penicillins

Pesticides

~174 compounds

Contents include a variety of pesticide-associated compounds such as:

Avermectin B_1a
Herbicidin A
Acephate
o,p'-DDT
Methiocarb
Ginkgoneolic acid

Stem Cell Modulators

>140 compounds

Contents include:

Differentiation inducers
Self-renewal and proliferation maintainers
Reprogramming efficiency enhancers

Terpenes

~95 compounds

Contents include many aromatic compounds such as:

(±)-Limonene
(±)-Linalool
β-Caryophyllene
α- and β-Pinene
Eucalyptol
Nerolidol
α-Humulene
(±)-Camphene
(+)-Borneol
Terpineol
(+)-Valencene

Lipid Screening

Bio-Active Lipids

Library I: >820 compounds
Library II: >190 compounds

Library I contents include:

Prostaglandins
Thromboxanes
Cannabinoids
D-myo-Inositol-phosphates
Phosphatidylinositol-phosphates
Sphingolipids
Inhibitors
Receptor agonists and antagonists
Ceramide derivatives
Other complex PUFAs

Library II contents include:

Prostaglandins
Isoprostanes
Thromboxanes
Leukotrienes
Lipoxins
Other complex PUFAs

D-myo-Inositol Phosphates

>37 compounds

Contents include a variety of D-myo-inositol phosphates, including:

D-myo-Inositol-1,4,5-triphosphate
D-myo-Inositol-1,4,5,6-tetraphosphate
D-myo-Inositol-1,2,3,4,5,6-hexaphosphate
D-myo-Inositol-1,4-diphosphate

Fatty Acids

>75 compounds

Contents include both common and unusual fatty acids such as:

Arachidonic acid
Linoleic acid
Eicosapentaenoic acid
Stearic acid
α-Linolenic acid
γ-Linolenic acid
Oleic acid
Palmitic acid
9-Thiastearic acid
2-Hydroxymyristic acid
AUDA
CUDA

Prostaglandins

Library I: >70 compounds
Library II: >60 compounds
Library III: >75 compounds

Library I contents include:

F-series prostaglandins and isoprostanes

Library II contents include:

D- and E-series prostaglandins

Library III contents include:

A- and J-series prostaglandins
Thromboxanes
Lactones
Stable PGH
Prostacyclin mimics
Metabolites
Potent PGA and PGJ analogs

Custom Discovery

BIONET Fragment Screening Libraries

Premium Library: >1,108 fragments
PROTAC Library: >658 fragments
Fluorine Library: >533 fragments

In collaboration with Key Organics, Cayman now offers BIONET Fragment Libraries for drug discovery. Each library contain aqueous soluble fragments and a complete data package rapidly to rapidly build fragment pools and initiate screening.

Each library is available in both dry and DMSO formats.

Custom Library

Tailor a library to your exact requirements

Design options:

Add or remove compounds

Have novel compounds synthesized
Choose from over 4,400 small molecule inhibitors in our inventory

Select solvent and desired concentration
Remove solvent (neat)
Request bar-coded vials
Request bulk quantity or specific size.

Make our experts an extension of your scientific staff

Activity Screening

We perform activity screening using your compounds, or our compound libraries, in biochemical or functional assays. Send us your samples—we’ll run the assays and deliver a professional report with results you can trust. Learn more.

Medicinal Chemistry & Structure-Based Drug Design

Whether it’s lead generation or optimization, route and methods development, screening, or scale-up, our scientists have the expertise and technology to bring your drug discovery program through pre-clinical stages of development. Learn more.

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​Cayman Compound Libraries

Advantages of Cayman Compound Libraries

Careful Curation

Competitive Pricing

Convenient Format

Hit Compound Availability

Library Customization

Choose from Multiple Screening Panels

Contents include:

Targets include HIV, HBV, HCV, influenza, HSV, coronaviruses, as well as malaria.

Contents include:

Contents include:

Contents include inducers and inhibitors of multiple cell death pathways:

Contents include modulators of:

Contents include modulators of:

Contents include:

Contents include:

Targets include:

Contents include a variety of microbiome metabolites such as:

Contents include a wide range of natural products, including:

Contents include a variety of pesticide-associated compounds such as:

Contents include:

Contents include many aromatic compounds such as:

Lipid Screening

Library I contents include:

Library II contents include:

Contents include a variety of D-myo-inositol phosphates, including:

Contents include both common and unusual fatty acids such as:

Library I contents include:

Library II contents include:

Library III contents include:

Custom Discovery

Design options:

Make our experts an extension of your scientific staff

Activity Screening

Medicinal Chemistry & Structure-Based Drug Design

Receive Our News & Literature Directly to Your Inbox!

Cayman Compound Libraries