For immunochemical detection of EL
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Endothelial Lipase Polyclonal Antibody

Item No. 100030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • EL
  • EDL
Immunogen
Synthetic peptide from the N-terminal region of human endothelial lipase
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Host
Rabbit
Applications
IHC, WB
Species Reactivity
(+) Human(+) Mouse(+) Ovine(+) Porcine(+) Rat
UniProt Accession №
Q9Y5X9
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Cayman Chemical
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    Product Description

    Endothelial lipase (EL) is a major genetic determinant for the concentration, structure, and metabolism of high-density lipoprotein, which protects against atherosclerosis.1,2 It was originally cloned from endothelial cells and found to be expressed in a distinct and complementary tissue-restricted fashion, with high-level expression in the liver, placenta, lung, ovary, and macrophage.3 Immunohistochemical studies demonstrate that EL is expressed in infiltrating cells such as macrophages within atheromatous plaques, in addition to endothelial and smooth muscle cells in non-atherosclerotic coronary arteries. Furthermore, EL expression is detected in the neovasculature within atheromatous plaques in atherosclerotic coronary arteries, indicating that EL may have unique functional roles in atherosclerosis.4 Cayman Chemical’s EL polyclonal antibody can be used for western blot and immunohistochemical analysis for EL on samples of human, murine, rat, porcine, and ovine origin. Other applications for use of this antibody have not yet been tested.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishida, T., Choi, S., Kundu, R.K., et al. Endothelial lipase is a major determinant of HDL level. J. Clin. Invest. 111(3), 347-355 (2003).

    2. Hirata, K.i., Dichek, H.L., Cioffi, J.A., et al. Cloning of a unique lipase from endothelial cells extends the lipase gene family. The Journal of Biological Chemisty 274(20), 14170-14175 (2003).

    3. Azumi, H., Hirata, K.i., Ishida, T., et al. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc. Res. 58(3), 647-654 (2003).

    Product Citations

    Schneider, P., Bindila, L., Schmahl, C., et al. Adverse social experiences in adolescent rats result in enduring effects on social competence, pain sensitivity and endocannabinoid signaling. Front. Behav. Neurosci. 10, (2016).

    Barrett, H.L., Kubala, M.H., Romero, K.S., et al. Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM). PLOS One 9(8), e104826 (2014).

    Jain, S., De Petris, L., Hoshi, M., et al. Expression profiles of podocytes exposed to high glucose reveal new insights into early diabetic glomerulopathy. Lab. Invest. 91(4), 488-498 (2011).