Obesity & Metabolic Disease Research Tools

Featured Tools for Obesity & Metabolic Disease Research

Reporter Assay Panel for Calcitonin and Amylin Receptors

CGRP dose-response curves for CTR, AMY1R, AMY2R, AMY3R

Investigate receptor selectivity and signaling with an easy-to-use, cell-based reporter assay panel designed for side-by-side analysis of CTR, AMY₁R, AMY₂R, and AMY₃R.

Key Features

High-throughput compatible
Positive control α-CGRP included

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TC4

Synthetic peptide and tetra-agonist of GLP-1R, GCGR, GIPR, and Y₂ receptor.

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Raptin (human, recombinant)

High-purity recombinant human protein for sleep-linked appetite and metabolic pathway research.

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BSA Metabolic Stress Reagent Set

BSA-fatty acid complexes with a paired control for cellular metabolic studies.

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Receptor Pharmacology

GLP-1 Receptor Agonists

Originally developed to treat type 2 diabetes, GLP-1 receptor agonists have found new therapeutic utility for obesity. GLP-1R is expressed in pancreatic beta cells, adipocytes, the brain, kidney, stomach, and heart. GLP-1 released from intestinal L-cells stimulates insulin biosynthesis, reduces glucagon secretion, and slows gastrointestinal motility to increase satiety. Cayman offers GLP-1R agonists for research use only.

VIEW ALL GLP-1R AGONISTS

Dual & Multi-Receptor Agonists

GLP-1 and GIP receptor agonists synergize, providing greater benefits than GLP-1 receptor agonists alone. These dual agonists, known as twincretins, also appear to reduce side effects through their complementary mechanisms of action. Glucagon receptor co-agonism further promotes satiety and increases energy expenditure through thermogenesis. Cayman offers a full range for research use only.

Tirzepatide (sodium salt) · Dual GLP-1R/GIPR agonist
Retatrutide (sodium salt) · Triple GLP-1R/GIPR/GCGR agonist
Survodutide (trifluoroacetate salt) · Dual GLP-1R/GCGR agonist
TC4 · Tetra GLP-1R/GCGR/GIPR/Y₂R agonist
Bamadutide · Dual GLP-1R/GCGR agonist

VIEW ALL DUAL GLP-1R AGONISTS VIEW ALL TRIPLE & TETRA GLP-1R AGONISTS

Explore the science behind GLP‑1, GIP, and glucagon receptor agonists in this Cayman News article

GLP-1, GIP, & GLP-2 Receptor Assays

Cayman offers cell-based reporter assay kits for functional characterization of GLP-1R, GIPR, and GLP-2R, enabling agonist potency determination, inhibitor screening, and comparative pharmacology across incretin and related receptor systems.

Screening therapeutic compounds that regulate the activation of GLP‑1R with GLP‑1 Receptor (Human) Reporter Assay Kit, Item No. 702940

Calcitonin & Amylin Receptors

The calcitonin receptor (CTR) heterodimerizes with RAMP1, RAMP2, or RAMP3 to form the AMY₁, AMY₂, and AMY₃ receptors, which regulate fat utilization, food intake, and glucose control. Amylin, co-secreted with insulin from pancreatic beta cells, induces satiety through homeostatic and hedonic regions of the brain via pathways complementary to GLP-1 with an additive effect on appetite reduction when combined. Cagrilintide, a long-acting amylin and calcitonin receptor agonist, is currently in phase 3 trials as CagriSema in combination with semaglutide.

DPP-IV Inhibitors & Assay

DPP-IV rapidly degrades incretins such as GLP-1, limiting their biological activity. DPP-IV inhibitors block this degradation, preserving native incretin bioactivity and enabling studies of endogenous GLP-1 physiology.

VIEW ALL DPP-IV INHIBITORS

Screening DPP (IV) inhibitors with DPP (IV) Inhibitor Screening Assay Kit, Item No. 700210

Endogenous Peptides & Hormones

GLP-1 Peptide Forms

GLP-1 is an incretin hormone released from the gut after eating. It stimulates insulin secretion, reduces post-meal blood glucose, slows gastric emptying, decreases gut motility, and reduces food intake and appetite. Cayman offers the endogenous GLP-1 peptides listed below, as well as a broader selection of exogenous GLP-1 peptides and analogs.

VIEW ALL GLP-1 PEPTIDES

Sequence of GLP‑1 (7‑36) amide (human, bovine, guinea pig, mouse, rat) (trifluoroacetate salt), Item No. 15069

Peptide Hormones in Metabolism

Peptide hormones regulate energy metabolism, food intake, and satiety through distinct pathways. Raptin, a recently identified sleep-inducible hypothalamic hormone, suppresses appetite and gastric emptying through GRM3 signaling, extending the biology of body weight regulation beyond the gut.

VIEW ALL PEPTIDE HORMONES RELATED TO FOOD INTAKE

Metabolic Signaling Assay Kits

Insulin Resistance & Glucose Homeostasis

Insulin and glucagon regulate blood glucose through opposing actions. Disruptions in glucose uptake and insulin signaling are central to the pathogenesis of type 2 diabetes and obesity.

VIEW ALL INSULIN-RELATED ASSAY KITS

Measuring dose‑dependent glucose uptake in Jurkat cells with Glucose Uptake Cell‑Based Assay Kit, Item No. 600470

Lipid Metabolism & Adipose Biology

Obesity is associated with elevated triglycerides, excess adipose accumulation, impaired lipolysis, and hepatic steatosis, a predisposing condition for MASLD that is also directly relevant to glucagon receptor biology.

VIEW ALL LIPID METABOLISM ASSAY KITS

Lipid droplet quantification in human hepatocyte model cells (Huh7) with BSA Metabolic Stress Reagent Set (Palmitate and Oleate BSA Complexes), Item No. 45544

PPAR Transcription Factor Assays

Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors that function as master regulators of carbohydrate and lipid metabolism. PPARα regulates fatty acid oxidation in the liver; PPARγ controls adipogenesis and insulin sensitivity; PPARδ modulates energy expenditure and lipid catabolism in muscle and adipose tissue. PPAR dysregulation is directly implicated in insulin resistance, dyslipidemia, and hepatic steatosis in obesity. Cayman offers 96-well transcription factor assay kits for quantifying PPAR DNA binding activity across all three subtypes.

VIEW ALL PPAR CELL-BASED REPORTER ASSAYS