A common dietary phenolic flavone
Related Products
Isomer(s)
15246Fisetin
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Luteolin

Item No. 10004161

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
CAS Number
491-70-3
Molecular Formula
C15H10O6
Formula Weight
286.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:5): 1 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
255, 348 nm
SMILES
Oc1cc(O)c2c(=O)cc(oc2c1)c1ccc(O)c(O)c1
InChi Code
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChi Key
IQPNAANSBPBGFQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $32

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    50 mg

    $72

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    100 mg

    $113

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    500 mg

    $479

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    Product Description

    Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.1 Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.2 Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ueda, H., Yamazaki, C., and Yamazaki, M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biol. Pharm. Bull. 25(9), 1197-1202 (2002).

    2. Sadik, C.D., Sies, H., and Schewe, T. Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action. Biochem. Pharmacol. 65(5), 773-781 (2003).

    3. Sartor, L., Pezzato, E., Dell'Aica, I., et al. Inhibition of matrix-proteases by polyphenols: Chemical insights for anti-inflammatory and anti-invasion drug design. Biochem. Pharmacol. 64(2), 229-237 (2002).