A flavonoid with diverse biological activities
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Fisetin

Item No. 15246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
CAS Number
528-48-3
Synonyms
  • CI-75620
  • NSC 407010
  • NSC 656275
Molecular Formula
C15H10O6
Formula Weight
286.2
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
250, 320, 364 nm
SMILES
O=C1C2=C(C=C(O)C=C2)OC(C3=CC=C(O)C(O)=C3)=C1O
InChi Code
InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
InChi Key
XHEFDIBZLJXQHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $37

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    500 mg

    $109

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    1 g

    $164

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    Cayman Chemical
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    Product Description

    Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.1,2,3,4 It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP; Item No. 21495) in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM.1,3 Fisetin (10-60 µM) induces cell cycle arrest at the G1 phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells.2 It inhibits LPS-induced production of nitrite, prostaglandin E2 (PGE2; Item No. 14010), and NF-κB activation in RAW 264.7 cells.3 Fisetin (1 mg/animal) reduces tumor growth in a CWR22Rυ1 prostate cancer mouse xenograft model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, N., Syed, D.N., Ahmad, N., et al. Fisetin: A dietary antioxidant for health promotion. Antioxid. Redox Signal. 19(2), 151-162 (2013).

    2. Khan, N., Afaq, F., Syed, D.N., et al. Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells. Carcinogenesis 29(5), 1049-1056 (2008).

    3. Wang, L., Tu, Y.-C., Lian, T.-W., et al. Distinctive antioxidant and antiinflammatory effects of flavonols. J. Agric. Food Chem. 54(26), 9798-9804 (2006).

    4. Khan, N., Asim, M., Afaq, F., et al. A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res. 68(20), 8555-8563 (2008).

    Product Citations

    Li, H., Puopolo, T., Seeram, N.P., et al. Anti-ferroptotic effect of cannabidiol in human skin keratinocytes characterized by data-independent acquisition-based proteomics. J. Nat. Prod. (2024).