For immunochemical detection of 11β-HSD1
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11β-Hydroxysteroid Dehydrogenase (Type 1) Polyclonal Antibody

Item No. 10004303

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Corticosteroid 11β-Dehydrogenase Isozyme 1
  • 11-DH
  • 11β-HSD1
  • Short Chain Dehydrogenase/Reductase Family 26C Member 1
Immunogen
Synthetic peptide from the an internal region of human 11β-HSD1
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IHC, WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
P28845
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Cayman Chemical
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    Product Description

    11β-Hydroxysteroid dehydrogenase (Type 1) (11β-HSD1) catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. mRNA and protein for this enzyme have been detected in a wide range of tissues including liver, kidney, testis, lung, heart, and colon.1 The enzyme’s expression is developmentally regulated, suggesting its importance in regulation of glucocorticoid action during embryonic development.2 Over-expression of 11β-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia.3 Cayman’s 11β-HSD1 Polyclonal Antibody detects a 32 kDa protein in human, mouse, and rat liver samples by western blot analysis. The antibody can be used on paraffin-embedded tissue sections to detect 11β-HSD1 expression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. White, P.C., Mune, T., and Agarwal, A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr. Rev. 18(1), 135-156 (1997).

    2. Thompson, A., Han, V.K., and Yang, K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. J. Steroid. Biochem. Mol. Biol. 88(4-5), 367-375 (2004).

    3. Masuzaki, H., Paterson, J., Shinyama, H., et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 294(5549), 2166-2170 (2001).

    Product Citations

    Beaudry, J.L., Dunford, E.C., Teich, T., et al. Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats. PLoS One 9(3), e91248 (2014).