An NSAID, a COX-2 inhibitor, and a prodrug form of sulindac sulfide
Related Products
Active Metabolite(s)
10004387Sulindac sulfide
Labeled Version(s)
33381Sulindac-d3
Metabolite(s)
16805Sulindac sulfone
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Sulindac

Item No. 10004386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
CAS Number
38194-50-2
Molecular Formula
C20H17FO3S
Formula Weight
356.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): .15 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): .05 mg/ml
λmax
226, 258, 286, 329 nm
SMILES
FC1=CC=C(/C(C(C)=C2CC(O)=O)=C\C3=CC=C(S(C)=O)C=C3)C2=C1
InChi Code
InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChi Key
MLKXDPUZXIRXEP-MFOYZWKCSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $16

    Add

    5 g

    $59

    Add

    10 g

    $98

    Add

    50 g

    $423

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Sulindac is a non-steroidal anti-inflammatory drug (NSAID), a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of the COX inhibitor sulindac sulfide (Item No. 10004387).1,2 It is selective for COX-2 over COX-1 (IC50 = >1,000 µM). 2 It inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats when administered at a dose of 100 mg/kg.3 Sulindac (60 mg/kg) reduces tumor growth in a BxPC-3 pancreatic cancer mouse xenograft model.4 Formulations containing sulindac have been used in the treatment of pain and inflammation associated with arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grossman, C.J., Wiseman, J., Lucas, F.S., et al. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors. Inflamm. Res. 44(6), 253-257 (1995).

    2. Duggan, D.E., Hooke, K.F., Noll, R.M., et al. Comparative disposition of sulindac and metabolites in five species. Biochem. Pharmacol. 27(19), 2311-2320 (1978).

    3. Bhat, M.A., Al-Omar, M.A., Alsaif, N.A., et al. Novel sulindac derivatives: Synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity. J. Enzyme Inhib. Med. Chem. 35(1), 921-934 (2020).

    4. Yip-Schneider, M.T., Wu, H., Ralstin, M., et al. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol. Cancer Ther. 6(6), 1736-1744 (2007).