An internal standard for the quantification of sulindac
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Unlabeled Version(s)
10004386Sulindac
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Sulindac-d3

Item No. 33381

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl-d3)phenyl]methylene]-1H-indene-3-acetic acid
Molecular Formula
C20H14D3FO3S
Formula Weight
359.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
OC(CC1=C(C)/C(C2=CC=C(F)C=C21)=C/C3=CC=C(C=C3)S(C([2H])([2H])[2H])=O)=O
InChi Code
InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-/i2D3
InChi Key
MLKXDPUZXIRXEP-FHFLIJIYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $134

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    1 mg

    $253

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    5 mg

    $1,058

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    Product Description

    Sulindac-d3 is intended for use as an internal standard for the quantification of sulindac (Item No. 10004386) by GC- or LC-MS. Sulindac is a non-steroidal anti-inflammatory drug (NSAID), selective COX-2 inhibitor (IC50s = 0.79 and >1,000 µM for COX-2 and COX-1, respectively), and prodrug form of sulindac sulfide (Item No. 10004387).1,2,3,4 Sulindac is reduced by intestinal bacteria to form sulindac sulfide.1 It inhibits acetic acid-induced writhing in mice and reduces paw edema induced by carrageenan in rats when administered at a dose of 100 mg/kg.3 Sulindac (60 mg/kg) reduces tumor growth in MiaPaCa-2 and BxPC-3 mouse xenograft models.4 Formulations containing sulindac have been used in the treatment of pain associated with arthritis, ankylosing spondylitis, and gout.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maseda, D., and Ricciotti, E. NSAID–gut microbiota interactions. Front. Pharmacol. 11, 1153 (2020).

    2. Grossman, C.J., Wiseman, J., Lucas, F.S., et al. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors. Inflamm. Res. 44(6), 253-257 (1995).

    3. Bhat, M.A., Al-Omar, M.A., Alsaif, N.A., et al. Novel sulindac derivatives: Synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity. J. Enzyme Inhib. Med. Chem. 35(1), 921-934 (2020).

    4. Yip-Schneider, M.T., Wu, H., Ralstin, M., et al. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Mol. Cancer Ther. 6(6), 1736-1744 (2007).