A selective antagonist of abnormal cannabidiol-mediated effects
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O-1918

Item No. 10004914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-benzene
CAS Number
536697-79-7
Molecular Formula
C19H26O2
Formula Weight
286.4
Purity
≥95%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:1): 0.5 mg/ml
SMILES
COC1=CC(C)=CC(OC)=C1[C@H]2[C@H](C(C)=C)CCC(C)=C2
InChi Code
InChI=1S/C19H26O2/c1-12(2)15-8-7-13(3)9-16(15)19-17(20-5)10-14(4)11-18(19)21-6/h9-11,15-16H,1,7-8H2,2-6H3/t15-,16+/m0/s1
InChi Key
ICHJMVMWPKLUKT-JKSUJKDBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    O-1918 is a cannabidiol analog that acts as a selective antagonist of abnormal cannabidiol at the non-CB1/CB2 endothelial receptor. It does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of abnormal cannabidiol in vitro and in whole animals.1 It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Offertáler, L., Mo, F.M., Bátkai, S., et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol. Pharmacol. 63(3), 699-705 (2003).

    Product Citations

    Schwartz, M., Bockmann, S., and Hinz, B. Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells. Oncotarget 9(77), 34595-34616 (2018).

    Matouk, A.I., Taye, A., El-Moselhy, M.A., et al. The effect of chronic activation of the novel endocannabinoid receptor GPR18 on myocardial function and blood pressure in conscious rats. J. Cardiovasc. Pharmacol. 69(1), 23-33 (2017).