A non-selective NOS inhibitor
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Alternative(s)
80200L-NMMA (citrate)
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L-NMMA (acetate)

Item No. 10005031

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-[imino(methylamino)methyl]-L-ornithine, monoacetate
CAS Number
53308-83-1
Synonyms
  • L-NG-monomethyl Arginine acetate
Molecular Formula
C7H16N4O2 • C2H4O2
Formula Weight
248.3
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.25 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H]N(C)C(N([H])CCC[C@H](N)C(O)=O)=N.CC(O)=O
InChi Code
InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)
InChi Key
IKPNWIGTWUZCKM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $19

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    25 mg

    $74

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    50 mg

    $130

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    100 mg

    $228

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    Product Description

    L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared.1 It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol. 268, 375-392 (1996).

    2. Frey, C., Narayanan, K., McMillan, K., et al. ʟ-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. The Journal of Biological Chemisty 269(42), 26083-26091 (1994).

    3. Garvey, E.P., Tuttle, J.V., Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Arch. Biochem. Biophys. 311(2), 235-241 (1994).