A non-selective NOS inhibitor
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Alternative(s)
10005031L-NMMA (acetate)
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L-NMMA (citrate)

Item No. 80200

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-[imino(methylamino)methyl]-L-ornithine, citrate
Synonyms
  • L-NG-monomethyl Arginine citrate
Molecular Formula
3[C7H16N4O2] • C6H8O7
Formula Weight
756.8
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: >6 mg/ml
SMILES
CN([H])/C(N([H])CCC[C@@H](C(O)=O)N)=N/[H].OC(CC(O)=O)(C(O)=O)CC(O)=O
InChi Code
InChI=1S/3C7H16N4O2.C6H8O7/c3*1-10-7(9)11-4-2-3-5(8)6(12)13;7-3(8)1-6(13,5(11)12)2-4(9)10/h3*5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
IJMNUUAADXBLAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $42

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    25 mg

    $69

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    50 mg

    $126

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    100 mg

    $209

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    Product Description

    L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared.1 The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol. 268, 375-392 (1996).

    2. Frey, C., Narayanan, K., McMillan, K., et al. ʟ-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. The Journal of Biological Chemisty 269(42), 26083-26091 (1994).

    3. Garvey, E.P., Tuttle, J.V., Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Arch. Biochem. Biophys. 311(2), 235-241 (1994).

    Product Citations

    Woldman, Y.Y., Sun, J.Z., J.L., and Khramtsov, V.V. Direct chemiluminescence detection of nitric oxide in aqueous solutions using the natural nitric oxide target soluble guanylyl cyclase. Free Radic. Biol. Med. 47(10), 1339-1345 (2009).