An S1P3 antagonist
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CAY10444

Item No. 10005033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-undecyl-4R-thiazolidinecarboxylic acid
CAS Number
298186-80-8
Synonyms
  • BML-241
Molecular Formula
C15H29NO2S
Formula Weight
287.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMF:PBS (pH 7.2) (1:3): 0.15 mg/ml
SMILES
[H]N1C(CCCCCCCCCCC)SC[C@H]1C(O)=O
InChi Code
InChI=1S/C15H29NO2S/c1-2-3-4-5-6-7-8-9-10-11-14-16-13(12-19-14)15(17)18/h13-14,16H,2-12H2,1H3,(H,17,18)
InChi Key
FNBSOIBCKUUVJJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $60

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    10 mg

    $108

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    25 mg

    $255

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    50 mg

    $451

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    Product Description

    CAY10444 is a sphingosine-1-phosphate receptor 3 (S1P3) antagonist.1 It inhibits S1P-induced calcium mobilization in CHO cells expressing human S1P3 (IC50 = 11.6 µM). CAY10444 (5 µM) inhibits S1P-induced growth and migration of MH7A rheumatoid fibroblast-like synoviocyte cells.2 It inhibits the localization and release of IL-1β and prostaglandin E2 (PGE2; Item No. 14010) in MH7A cells when used at a concentration of 5 µM. CAY10444 (17.4 µM) also inhibits Na+/K+-ATPase activity in HepG2 cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koide, Y., Hasegawa, T., Takahashi, A., et al. Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. J. Med. Chem. 45(21), 4629-4638 (2002).

    2. Wang, M., Wu, H., Wang, R., et al. Inhibition of sphingosine 1-phosphate (S1P) receptor ½/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing. Clin. Exp. Pharmacol. Physiol. 48(8), 1080-1089 (2021).

    3. Al Alam, N., and Kreydiyyeh, S.I. FTY720P inhibits hepatic Na+-K+ ATPase via S1PR2 and PGE2. Biochem. Cell Biol. 94(4), 371-377 (2016).

    Product Citations

    Wang, M., Wu, H., Wang, R., et al. Inhibition of sphingosine 1-phosphate (S1P) receptor ½/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing. Clin. Exp. Pharmacol. Physiol. 48(8), 1080-1089 (2021).

    Al Alam, N., and Kreydiyyeh, S.I. FTY720P inhibits hepatic Na+-K+ ATPase via S1PR2 and PGE2. Biochem. Cell Biol. 94(4), 371-377 (2016).

    Beach, J.A., Aspuria, P.J., Cheon, D.J., et al. Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer. Oncotarget 7(4), 4167-4182 (2016).