TOFA

TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).¹ Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FASN inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.

WARNING This product is not for human or veterinary use.

1. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288(5475), 2379-2381 (2000).

Desseaux, V., Koukiekolo, R., Moreau, Y., et al. Mechanism of porcine pancreatic α-amylase: Inhibition of amylose and maltopentaose hydrolysis by various inhibitors. Biologia 57(Suppl 11), 163-170 (2002).