(−)-L-threo-PDMP (hydrochloride)

(–)-L-threo-PDMP is a ceramide derivative and one of the four possible stereoisomers of PDMP (Item No. 62595).¹ L-threo-PDMP is an enhancer of ganglioside biosynthesis.² It increases the activity of ganglioside G_M3, -G_D3, and -G_Q1b synthases and the levels of various gangliosides in primary rat cortical neurons, as well as increases the levels of glucosylceramide, lactosylceramide, and ganglioside G_M3 in B16 melanoma cells.^2,3 L-threo-PDMP increases neurite outgrowth in primary rat neocortical explants when used at a concentration of 15 µM and increases functional synapse formation in primary rat cortical neurons at 20 µM.^4,2 It improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered after ischemia at a dose of 40 mg/kg per day.² [Matreya, LLC. Catalog No. 1749]

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1. Inokuchi, J.i., and Radin, N.S. Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. J. Lipid Res. 28(5), 565-571 (1987).

2. Inokuchi, J.-i., Mizutani, A., Jimbo, M., et al. Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP). Biochm. Biophys. Res. Commun. 237(3), 595-600 (1997).

3. Inokuchi, J.-i. Neurotrophic and neuroprotective actions of an enhancer of ganglioside biosynthesis. Int. Rev. Neurobiol. 85, 319-336 (2009).

4. Usuki, S., Hamanoue, M., Kohsaka, S., et al. Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. J. Neurochem. 67(5), 1821-1830 (1996).