A diterpene amine with diverse biological activities
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Alternative(s)
10008614Leelamine (hydrochloride)
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Leelamine

Item No. 10006148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine
CAS Number
1446-61-3
Synonyms
  • Dehydroabietylamine
  • NSC 2955
Molecular Formula
C20H31N
Formula Weight
285.5
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 100 mg/mlEthanol:PBS (pH 7.2) (1:3): .25 mg/ml
SMILES
CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3
InChi Code
InChI=1S/C20H31N/c1-14(2)15-6-8-17-16(12-15)7-9-18-19(3,13-21)10-5-11-20(17,18)4/h6,8,12,14,18H,5,7,9-11,13,21H2,1-4H3/t18-,19-,20+/m0/s1
InChi Key
JVVXZOOGOGPDRZ-SLFFLAALSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    25 mg

    $178

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    50 mg

    $312

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    Product Description

    Leelamine is a diterpene amine that has been found in gum resin and has diverse biological activities.1,2,3 It inhibits pyruvate dehydrogenase kinase (PDHK; IC50 = 9.5 µM).1 Leelamine is active against the plant pathogenic fungus B. cinerea (EC50 = 70 µM).2 It induces apoptosis in UACC-903 and 1205Lu melanoma cell lines when used at a concentration of 3 µM.3 Leelamine (100 and 300 µmol/kg per day) reduces blood glucose levels in an ob/ob mouse model of type II diabetes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg. Med. Chem. Lett. 9(15), 2223-2228 (1999).

    2. Yoshida, M., Kawasaki, A., Yukimoto, M., et al. Detection of the effects of fungicides on the cell membrane by proton nuclear magnetic resonance spectroscopy. Pest. Biochem. Phys. 38(2), 172-177 (1990).

    3. Kuzu, O.F., Gowda, R., Sharma, A., et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol. Cancer Ther. 13(7), 1690-1703 (2014).