An inhibitor of pyruvate dehydrogenase kinase
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Alternative(s)
10006148Leelamine
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Leelamine (hydrochloride)

Item No. 10008614

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, monohydrochloride
CAS Number
16496-99-4
Synonyms
  • Dehydroabietylamine
Molecular Formula
C20H31N • HCl
Formula Weight
321.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.15 mg/mlEthanol: 20 mg/ml
SMILES
CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3.Cl
InChi Code
InChI=1S/C20H31N.ClH/c1-14(2)15-6-8-17-16(12-15)7-9-18-19(3,13-21)10-5-11-20(17,18)4;/h6,8,12,14,18H,5,7,9-11,13,21H2,1-4H3;1H/t18-,19-,20+;/m0./s1
InChi Key
CVPQLGCAWUAYPF-WFBUOHSLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

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    10 mg

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    50 mg

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    100 mg

    $655

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    Product Description

    Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means “play”. It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.1 Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 of 9.5 µM.2 Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martin, B.R. Leelamine. (2006).

    2. Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg. Med. Chem. Lett. 9(15), 2223-2228 (1999).

    3. Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. Eur. J. Med. Chem. 26(7), 667-676 (1991).