For immunochemical detection of HSL
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Hormone-Sensitive Lipase Polyclonal Antibody

Item No. 10006371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • HSL
  • LIPE
Immunogen
Synthetic peptide from the C-terminal region of human HSL receptor
Formulation (Request formulation change)
Peptide affinity-purified IgG
Storage Buffer
TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
WB
Species Reactivity
(+) Human HSL(+) Mouse HSL(+) Ovine HSL(+) Rat HSL
UniProt Accession №
Q05469
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µl

    $347

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    Cayman Chemical
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    Product Description

    Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters and thus mobilizes fatty acid and provides a primary source of energy in mammals.1 The enzyme is highly expressed in adipose tissue and steroidogenic tissues, and less abundantly in skeletal muscle, heart, brain, pancreatic beta cells, adrenal gland, ovaries, testes, and macrophages. Its presence in various tissues indicates the enzyme plays diverse roles including those in steroidogenesis and spermatogenesis, foam cell formation in atherosclerosis, and diabetic pathology.1,2 Human HSL cDNA encodes a 775 amino acid protein with an estimated molecular size of 84 kDa.3 A second, larger isoform encoded by a unique testis mRNA was later identified.4,5 Cayman’s HSL Polyclonal Antibody can be used for Western blot applications. The antibody recognizes HSL at 86 kDa from human, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saltiel, A.R. Another hormone-sensitive triglyceride lipase in fat cells. Proc. Natl. Acad. Sci. USA 97(2), 535-537 (2000).

    2. Kraemer, F.B., and Shen, W.J. Hormone-sensitive lipase: Control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis. J. Lipid. Res. 43(10), 1585-1594 (2002).

    3. Langin, D., Laurell, H., Holst, L., et al. Gene organization and primary structure of human hormone-sensitive lipase: Possible significane of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. Proc. Natl. Acad. Sci. USA 90(11), 4897-4901 (2005).

    4. Holst, L.S., Langin, D., Mulder, H., et al. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. Genomics 35(3), 441-447 (1996).

    5. Mairal, A., Melaine, N., Laurell, H., et al. Characterization of a novel testicular form of human hormone-sensitive lipase. Biochem. Biophys. Res. Commun. 291(2), 286-290 (2002).

    Product Citations

    Flores-Costa, R., Alcaraz-Quiles, J., Titos, E., et al. The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis. Br. J. Pharmac. 175(6), 953-967 (2018).

    Wu, M.-R., Hou, M.-H., Lin, Y.-L., et al. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. J. Agric. Food Chem. 60(29), 7262-7269 (2012).