Analog of S1P
Related Products
Enantiomer(s)
10006408FTY720 (S)-Phosphate
Isomer(s)
10008639FTY720 Phosphate
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FTY720 (R)-Phosphate

Item No. 10006407

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol
CAS Number
402616-23-3
Molecular Formula
C19H34NO5P
Formula Weight
387.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 0.5 mg/ml
SMILES
CCCCCCCCc1ccc(cc1)CC[C@@](N)(CO)COP(=O)(O)O
InChi Code
InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)/t19-/m1/s1
InChi Key
LRFKWQGGENFBFO-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $69

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    1 mg

    $127

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    5 mg

    $525

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    10 mg

    $918

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    Product Description

    FTY720 (R)-phosphate is one of the stereoisomers of FTY720-phosphate, but it is apparently not formed in vivo.1 FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R isomer binds with 5 to 130-fold lower affinity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Albert, R., Hinterding, K., Brinkmann, V., et al. Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. J. Med. Chem. 48(16), 5373-5377 (2005).

    2. Kiuchi, M., Adachi, K., Tomatsu, A., et al. Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg. Med. Chem. 13(2), 425-432 (2005).