The active metabolite of FTY720
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FTY720 Phosphate

Item No. 10008639

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, 1-(dihydrogen phosphate)
CAS Number
402615-91-2
Synonyms
  • FTY720P
Molecular Formula
C19H34NO5P
Formula Weight
387.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 0.5 mg/mlDMSO: Slightly soluble*
SMILES
CCCCCCCCC1=CC=C(CCC([NH3+])(COP([O-])(O)=O)CO)C=C1
InChi Code
InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)
InChi Key
LRFKWQGGENFBFO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $109

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    5 mg

    $491

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    10 mg

    $818

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    25 mg

    $1,770

    Add
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    Product Description

    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1 In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2,3 FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brinkmann, V., Pinschewer, D.D., Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72(5), 764-769 (2001).

    2. Brinkmann, V., Davis, M.D., Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemisty 277(24), 21453-21457 (2002).

    3. Mandala, S., Hajdu, R., Bergstrom, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296(5566), 346-349 (2002).

    4. Forrest, M., Sun, S.Y., Hajdu, R., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther. 309(2), 758-768 (2004).

    Product Citations

    Cavalcanti, F., Gonzalez-Rey, E., Delgado, M., et al. Efficacy of vafidemstat in experimental autoimmune encephalomyelitis highlights the KDM1A/RCOR1/HDAC epigenetic axis in multiple sclerosis. Pharmaceutics 14(7), 1420 (2022).

    Harris, C.M., Mittelstadt, S., Banfor, P., et al. Sphingosine-1-phosphate (S1P) lyase inhibition causes increased cardiac S1P levels and bradycardia in rats. J. Pharmacol. Exp. Ther. 359(1), 151-158 (2016).

    Lim, K.G., Tonelli, F., Berdyshev, E., et al. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. Int. J. Biochem. Cell Biol. 44(9), 1457-1464 (2012).