A primary, naturally-occurring estrogen
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Estrone

Item No. 10006485

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-estra-1,3,5(10)-trien-17-one
CAS Number
53-16-7
Synonyms
  • E1
Molecular Formula
C18H22O2
Formula Weight
270.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:5): .15 mg/mlDMSO: 20 mg/ml
λmax
281 nm
SMILES
Oc1ccc2c(CC[C@@H]3C2CC[C@]2(C)C(=O)CCC32)c1
InChi Code
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChi Key
DNXHEGUUPJUMQT-CBZIJGRNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $14

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    1 g

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    5 g

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    10 g

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    Product Description

    Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol.1 Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.1,2 Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.1 The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gruber, C.J., Tschugguel, W., Schneeberger, C., et al. Production and actions of estrogens. N. Engl. J. Med. 346(5), 340-352 (2002).

    2. Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988).