Oleyl Anilide

Oleyl anilide is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC₅₀ = 26 µM).¹ It induces splenomegaly in C57BL/6 mice and leads to weakness, weight loss, cachexia, and death in A/J mice with increases in serum IgG and IgM levels in both strains.² Oleyl anilide has been found in aniline-denatured rapeseed cooking oil, which has been associated with toxic oil syndrome, a chemically induced autoimmune syndrome characterized by acute pulmonary inflammation and eosinophilia, severe myalgia, and chronic peripheral neuropathy.^3,4,5

WARNING This product is not for human or veterinary use.

1. Roth, B.D., Blankley, C.J., Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J. Med. Chem. 35(9), 1609-1617 (1992).

2. Berking, C., Hobbs, M.V., Chatelain, R., et al. Strain-dependent cytokine profile and susceptibility to oleic acid anilide in a murine model of the toxic oil syndrome. Toxicol. Appl. Pharmacol. 148(2), 222-228 (1998).

3. Gelpi, E., de la Paz, M.P., Terracini, B., et al. The spanish toxic oil syndrome 20 years after its onset: A multidisciplinary review of scientific knowledge. Environ. Health Perspect. 110(5), 457-464 (2002).

4. Posada de la Paz, M., Philen, R.M., and Borda, A.I. Toxic oil syndrome: The perspective after 20 years. Epidemiol. Rev. 23(2), 231-247 (2001).

5. Hard, G.C. A search for an animal model of the Spanish toxic oil syndrome. Food Chem. Toxicol. 40(11), 1551-1567 (2002).