A dietary ω-6 PUFA
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γ-Linolenic Acid methyl ester

Item No. 10006579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6Z,9Z,12Z-octadecatrienoic acid, methyl ester
CAS Number
16326-32-2
Synonyms
  • Methyl GLA
  • Methyl γ-Linolenate
  • SFE 19:3
Molecular Formula
C19H32O2
Formula Weight
292.5
Purity
≥98%
Formulation
A 250 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: 1 mg/mlDMF: 100 mg/mlDMSO: 100 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): .15 mg/ml
SMILES
CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O
InChi Code
InChI=1S/C19H32O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21-2/h7-8,10-11,13-14H,3-6,9,12,15-18H2,1-2H3/b8-7-,11-10-,14-13-
InChi Key
JFRWATCOFCPIBM-JPFHKJGASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $36

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    100 mg

    $68

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    250 mg

    $153

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    1 g

    $402

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    Product Description

    γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.1 GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).