A specific p38 MAPK inhibitor
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PD 169316

Item No. 10006727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]-pyridine
CAS Number
152121-53-4
Molecular Formula
C20H13FN4O2
Formula Weight
360.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS (pH 7.2) (1:2): 0.25 mg/mlDMSO: 2 mg/ml
λmax
229, 365 nm
SMILES
FC1=CC=C(C=C1)C2=C(C3=CC=NC=C3)NC(C4=CC=C([N+]([O-])=O)C=C4)=N2
InChi Code
InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
InChi Key
BGIYKDUASORTBB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

    $185

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    25 mg

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    Product Description

    PD 169316 is a selective inhibitor of p38 MAPK.1 It inhibits p38 MAPK with an IC50 of 89 nM, whereas the IC50s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα.1 PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gallagher, T.F., Seibel, G.L., Kassis, S., et al. Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinase. Bioorg. Med. Chem. 5(1), 49-64 (1997).

    2. Nath, R., McGinnis, K., Dutta, S., et al. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell. Mol. Biol. Lett. 6, 173-184 (2001).

    3. Kummer, J.L., Rao, P.K., and Heidenreich, K.A. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of Biological Chemisty 272(33), 20490-20494 (1997).