Kinase Research Tools
Helping Make Your Kinase Research Possible
Kinase signaling regulates myriad physiological processes from cellular proliferation, differentiation, and death to immune function, inflammation, and angiogenesis. Cayman’s broad collection of kinase inhibitors, antibodies, proteins, and assay kits has been designed to study kinase function and signaling pathways in a variety of physiological and pathological contexts.
Featured Products for Kinase Research
Kinase Screening Library (96-Well)
- Contains ~160 kinase inhibitors targeting more than 70 distinct kinases and kinase families
- Includes inhibitors of lipid, receptor and non-receptor tyrosine, serine/threonine, and dual specificity kinases
- Targets include the ROCK, ALK, GSK3, PKC, PDGFR, VEGFR, Src, MAPK, CDK, and PI3K families, among many others
Comprehensive Kinase Screening Library (96-Well)
- Contains more than 850 kinase inhibitors, providing greater coverage of individual kinases, kinase isoforms and mutants, and kinase families
Kinase Inhibitors
Cayman offers more than 1,300 selective and non-selective kinase inhibitors to modulate kinase-dependent signaling pathways. Browse our extensive and continuously expanding line of kinase inhibitors.
We also supply negative controls, as well as kinase activators and phosphatase inhibitors for further modulation of kinases and kinase-dependent signaling pathways.
Need Help Choosing the Right Kinase Inhibitor for Your Research?
There are many factors to consider when evaluating the experimental suitability of small molecule inhibitors. Inhibitors that meet stringent potency, selectivity, and activity criteria can be used as chemical probes to modulate and study target protein function. Explore Cayman’s resources to help you choose the right kinase inhibitor for your specific application.
KINASE SIGNALING PATHWAYS
Use the signal transduction cascades inside this brochure to explore Cayman’s broad selection of inhibitors targeting specific nodes of the major kinase signaling pathways.
DOWNLOAD THE BROCHURECHOOSING & USING CHEMICAL PROBES
Chemical probes are well-characterized small molecules that potently and selectively modulate target protein activity. We partnered with the SGC to develop a visual guide with resources and criteria to help you choose the best chemical probe for your experiments.
DOWNLOAD THE GUIDESMALL MOLECULE INHIBITORS SELECTION GUIDE
In this article, we dig deeper into the list of parameters that should be considered during the inhibitor selection process.
READ THE ARTICLEGrowth Factor Signaling
Growth factor signaling regulates numerous cellular processes under physiological and pathological conditions, including differentiation, survival, migration, and proliferation. Signaling through TGF-βRI and TGF-βRII, which are growth factor receptors with serine/threonine kinase activity, activates the SMAD pathway. Activation of growth factor receptors with receptor tyrosine kinase activity, such as IGF-1R, EGFRs, FGFRs, VEGFRs, and PDGFRs, signals through the PLC/PKC, PI3K/Akt, and/or RAS/RAF/MEK/ERK MAPK pathways. Alterations to growth factor receptors contribute to cancer initiation, progression, angiogenesis, and metastasis. More than 85% of FDA-approved small molecule kinase inhibitors are indicated for the treatment of neoplasms, with growth factor receptors belonging to the EGFR, FGFR, PDGFR, and VEGFR families as some of the most common targets of these inhibitors.
IGF-1R
EGFR/ErbB/HER Family
- EGF Proteins
- EGFR/ErbB/HER Family Proteins
- EGFR/ErbB/HER Family Antibodies
- EGFR/ErbB/HER Family Assay Kits
- EGFR/ErbB/HER Family Inhibitors
PDGFR Family
- PDGFRα/CD140a (human, recombinant)
- PDGFRβ/CD140b Extracellular Domain (human, recombinant)
- FLT3/CD135 Intracellular Domain (human, recombinant)
- PDGFRβ/CD140b (C-Term) Rabbit Monoclonal Antibody
- c-Kit/CD117 (C-Term) Rabbit Monoclonal Antibody
- PDGFR Family Inhibitors
VEGFR Family
- VEGF Proteins and Antibodies
- VEGFR2 Extracellular Domain (human, recombinant; aa 20-327)
- VEGFR3 Extracellular Domain (human, recombinant)
- Human Vascular Endothelial Growth Factor Receptor 2 Reporter Assay System
- VEGFR Family Inhibitors
FGFR Family
PKC
TGF-βR/SMAD Pathway
LEARN MORE ABOUT THE ROLE OF GROWTH FACTOR RECEPTORS IN CANCER
READ THE ARTICLEPI3K/Akt/mTOR Pathway
Signaling through the PI3K/Akt/mTOR pathway regulates processes including proliferation, apoptosis, metabolism, and angiogenesis, with important roles in human diseases including ischemic brain injury, neurodegeneration, diabetes, and cancer. Following activation by cellular receptors, PI3K converts PIP2 to the second messenger PIP3, which recruits PDK1 and Akt to the cell membrane where they are activated. Akt signals through downstream proteins including GSK3, MDM2, and mTOR to regulate various cellular functions.
PI3K
PDK1
Akt
mTOR, 4E-BP1, and S6K
- mTOR/mLST8/Raptor Complex (human, recombinant)
- mTOR Rabbit Monoclonal Antibody
- mTOR Inhibitors
- 4E-BP1 Assay Kits
- S6K Inhibitors
MDM2 and p53
- p53 (Phospho-Ser392) Polyclonal Antibody
- p53 Monoclonal Antibody (Clone BP53-12)
- p53 (N-Term) Rabbit Monoclonal Antibody
- p53 Transcription Factor Assay Kit
- MDM2-p53 Interaction Inhibitors
GSK3
- GSK3β (human, recombinant)
- GSK3β (Phospho-Ser9) Polyclonal Antibody
- GSK3β Assay Kits
- GSK3 Inhibitors
Bad and NF-κB
- Bad (Phospho-Ser112) TR-FRET Assay Kit
- NF-κB (p50) (human, recombinant)
- NF-κB (p65) (human, recombinant)
- NF-κB Antibodies
- NF-κB Assay Kits
MAPK Signaling Pathways
MAPKs are serine/threonine protein kinases that regulate processes including cell differentiation, proliferation, survival, and apoptosis, as well as inflammation. Activation of the ERK, JNK, and p38 MAPK pathways in response to growth factors, cytokines, and other stimuli leads to sequential phosphorylation of MAP3Ks, MAP2Ks, and MAPKs, followed by phosphorylation of diverse target proteins and transcription factors that influence cellular functions.
RAF/MEK/ERK Pathway
- B-RAF Rabbit Monoclonal Antibody
- B-RAFV600E Monoclonal Antibody
- Raf-1 (Phospho-Ser301) Polyclonal Antibody
- Raf-1 (Phospho-Ser642) Polyclonal Antibody
- RAF Inhibitors
- MEK Antibodies
- MEK Assay Kits
- MEK Inhibitors
- ERK/MAPK Polyclonal Antibody
- ERK/MAPK (Phospho-Thr202/Tyr204) Polyclonal Antibody
- ERK Assay Kits
- ERK Inhibitors
JNK and p38 MAPK Pathways
- MAP3K Inhibitors
- JNK1/2/3 (Phospho-Thr183/Tyr185) Rabbit Monoclonal Antibody
- JNK Assay Kits
- JNK Inhibitors
- p38 MAPK Antibodies
- p38 MAPK Assay Kits
- p38 MAPK Inhibitors
JAK/STAT Signaling Pathway
JAK/STAT signaling regulates cell proliferation, differentiation, migration, and apoptosis in response to cytokines and growth factors. In canonical JAK/STAT signaling, binding of type I/II cytokines to their cognate receptors activates receptor-associated JAKs, which then phosphorylate STATs to induce transcription. The JAK/STAT pathway regulates inflammation, the immune response, and hematopoiesis and is implicated in numerous inflammatory and autoimmune diseases.
- JAK1 (human, recombinant)
- JAK2 (human, recombinant)
- TYK2 (human, recombinant)
- JAK Family Inhibitors
- STAT1β (human, recombinant)
- STAT3α/β (N-Term) Rabbit Monoclonal Antibody
- STAT3α/β (Phospho-Tyr705) Rabbit Monoclonal Antibody
- STAT Assay Kits
LEARN MORE ABOUT CALMING THE CYTOKINE STORM THROUGH KINASE INHIBITION
READ THE ARTICLETools to Study Protein Kinase Substrates
Kinases phosphorylate a wide range of cellular targets including carbohydrates, lipids, and proteins. Cayman offers several TR-FRET assay kits and more than 60 phospho-specific antibodies for the detection of specific phosphorylated protein kinase substrates including transcription factors, kinases, adaptors, translation initiation regulators, histones, transporters, receptors, and more.
Learn more about methods for detecting kinase activity
- Cell Reporter Assays
- TR-FRET Assays
- Kinase Inhibitor Screening Assays
- Phospho-Specific Antibodies and Recombinant Kinases