A non-fibrate hypolipidemic drug
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Cetaben

Item No. 10007171

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(hexadecylamino)-benzoic acid
CAS Number
55986-43-1
Synonyms
  • Hexadecylamino-p-amino Benzoic Acid
Molecular Formula
C23H39NO2
Formula Weight
361.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.15 mg/mlEthanol: 1 mg/ml
λmax
224, 304 nm
SMILES
CCCCCCCCCCCCCCCCNC1=CC=C(C(O)=O)C=C1
InChi Code
InChI=1S/C23H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-24-22-18-16-21(17-19-22)23(25)26/h16-19,24H,2-15,20H2,1H3,(H,25,26)
InChi Key
QXWKHSSBFQDQPR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $73

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    50 mg

    $302

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    100 mg

    $525

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    The fibrate class of hypolipidemic drugs such as clofibrate and fenofibrate elicit their effects by binding to and activating peroxisome proliferator-activated receptor α (PPARα). Cetaben is a unique, peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator with hypolipidemic activity, characterized by reduction in serum triglyceride and cholesterol concentrations in rats.1 In male wistar rats, cetaben increased the activity of all peroxisomal enzymes examined in liver and kidney, whereas clofibrate showed a varied regulatory pattern.2 In addition to its effects on peroxisomes, cetaben inhibits cholesterol synthesis in the human hepatoma HepG2 cells resulting in reversible changes in Golgi morphology.3,4 It also blocked triglyceride synthesis by 99% and reduced cholesterol ester synthesis by >70% at a concentration of 50 µM in these same cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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