A cyanotoxin and an inhibitor of PP1C and PP2A
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Microcystin-LA

Item No. 10007187

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
CAS Number
96180-79-9
Synonyms
  • Cyanoginosin-LA
  • MC-LA
  • Toxin BE4 (M. aeruginosa)
Molecular Formula
C46H67N7O12
Formula Weight
910.1
Purity
≥95%
Formulation (Request formulation change)
A clear film
Solubility(Learn about Variance in Solubility)
Ethanol: SolubleMethanol: Soluble
SMILES
CC(/C=C/[C@@H]([C@H](C)C(N[C@@H](C(O)=O)CCC(N(C)C(C(N[C@@H]1C)=O)=C)=O)=O)NC([C@H](C)NC([C@@]([H])(C)[C@H](C(O)=O)NC([C@]([H])(CC(C)C)NC1=O)=O)=O)=O)=C\[C@@H]([C@H](CC2=CC=CC=C2)OC)C
InChi Code
InChI=1S/C46H67N7O12/c1-24(2)21-35-44(60)52-38(46(63)64)28(6)40(56)47-29(7)41(57)49-33(18-17-25(3)22-26(4)36(65-11)23-32-15-13-12-14-16-32)27(5)39(55)50-34(45(61)62)19-20-37(54)53(10)31(9)43(59)48-30(8)42(58)51-35/h12-18,22,24,26-30,33-36,38H,9,19-21
InChi Key
DIAQQISRBBDJIM-DRSCAGMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 µg

    $135

    Add

    100 µg

    $432

    Add

    1 mg

    $3,510

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Microcystin-LA is a cyanotoxin and an inhibitor of protein phosphatase 1C (PP1C) and PP2A (IC50 = 0.3 nM for both).1 In vivo, microcystin-LA (7 mg/kg) induces moribundity and increases liver-to-body weight ratios and serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), and glutamate dehydrogenase (GDH), markers of hepatotoxicity, in mice.2 Microcystin-LA has been found in freshwater with cyanobacterial blooms.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aggen, J.B., Humphrey, J.M., Gauss, C.M., et al. The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: Rational modifications imparting PP1 selectivity. Bioorg. Med. Chem. 7(3), 543-564 (1999).

    2. Chernoff, N., Hill, D., Lang, J., et al. Dose-response study of microcystin congeners MCLA, MCLR, MCLY, MCRR, and MCYR administered orally to mice. Toxins (Basel) 13(2), 86 (2021).

    3. Skafi, M., Vo Duy, S., Munoz, G., et al. Occurrence of microcystins, anabaenopeptins and other cyanotoxins in fish from a freshwater wildlife reserve impacted by harmful cyanobacterial blooms. Toxicon 194, 44-52 (2021).