A cyanotoxin and an inhibitor of PP2A
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Microcystin-LR

Item No. 10007188

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
CAS Number
101043-37-2
Synonyms
  • Cyanoginosin-LR
  • Toxin T 17 (M. aeruginosa)
  • MC-LR
Molecular Formula
C49H74N10O12
Formula Weight
995.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlEthanol: 10 mg/mlMethanol: 10 mg/mlWater: Soluble
SMILES
C[C@@H](/C=C(/C=C/[C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](C)[C@H](C(O)=O)NC1=O)=O)=O)[C@H](C)C(N[C@@H](C(O)=O)CCC(N(C(C(N[C@H](C)C(N[C@H]1CC(C)C)=O)=O)=C)C)=O)=O)C)[C@@H](OC)CC2=CC=CC=C2
InChi Code
InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-1
InChi Key
ZYZCGGRZINLQBL-DABAWSACSA-N
Origin
Bacterium/Microcystis aeruginosa
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Microcystin-LR is a cyanotoxin and an inhibitor of protein phosphatase 2A (PP2A; Ki = 9 pM).1 It selectively inhibits PP2A over PP1C and PP1γ (Kis = 180 and 240 pM, respectively). Intratracheal administration of microcystin-LR (100 µg/kg) induces hepatic bleeding in mice. Microcystin-LR has been found in freshwater with cyanobacterial blooms.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, E., Takai, A., Kondo, F., et al. Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 40(7), 1017-1025 (2002).

    2. Romera-García, E., Helmus, R., Ballesteros-Gómez, A., et al. Multi-class determination of intracellular and extracellular cyanotoxins in freshwater samples by ultra-high performance liquid chromatography coupled to high resolution mass spectrometry. Chemosphere 274, 129770 (2021).