For immunochemical detection of GPR40
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FFAR1 (GPR40) Polyclonal Antibody

Item No. 10007205

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Free Fatty Acid Receptor 1
  • G Protein-Coupled Receptor 40
Immunogen
human GPR40
Formulation (Request formulation change)
500 μl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IHC and WB
Species Reactivity
(+) Human GPR40(+) Rat GPR40(+) Mouse GPR40(+) Porcine GPR40
UniProt Accession №
O14842
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids.1,2 Found predominantly in the β-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion.3,4 Overexpression of GPR40 in mouse β cells leads to glucose intolerance suggesting a link between GPR40 expression and diabetes.3,4 The receptor has also been identified as a possible mediator of oleate- and linoleate- stimulated proliferation of the human breast cancer cell line, MCF-7.5,6 GPR40 has a calculated mass of 31.4 kDa bases on its amino acid sequence.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sawzdargo, M., George, S.R., Nguyen, T., et al. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem. Biophys. Res. Commun. 239, 543-547 (1997).

    2. Itoh, Y., Kawamata, Y., Harada, M., et al. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40. Nature 422(6928), 173-176 (2003).

    3. Briscoe, C.P., Peat, A.J., McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. Br. J. Pharmacol. 148(5), 619-628 (2006).

    4. Yonezawa, T., Katoh, K., and Obara, Y. Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. Biochem. Biophys. Res. Commun. 314, 805-809 (2004).

    5. Steneberg, P., Rubins, N., Bartoov-Shifman, R., et al. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab. 1(4), 245-258 (2005).

    6. Hardy, S., St-Onge, G.G., Joly, E., et al. Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. The Journal of Biological Chemisty 280(14), 13285-13291 (2005).