A derivative of PGH1
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9,11-methane-epoxy Prostaglandin F1α

Item No. 10007850

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1α,4α,5β,6α(1E,3S*)]-6-(3-hydroxy-1-octenyl)-2-oxabicyclo[2.2.1]heptane-5-heptanoic acid
CAS Number
72517-81-8
Synonyms
  • 9,11-epoxymethano PGH1
  • 9,11-methane-epoxy PGF1α
Molecular Formula
C21H36O4
Formula Weight
352.5
Purity
≥96%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
CCCCC[C@H](O)/C=C/[C@H]1C2OCC(C2)[C@@H]1CCCCCCC(O)=O
InChi Code
InChI=1S/C21H36O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h12-13,16-20,22H,2-11,14-15H2,1H3,(H,23,24)/b13-12+/t16-,17+,18-,19-,20-/m1/s1
InChi Key
VGRVXLWYKKBTNM-CQGVCJOOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    9,11-methane-epoxy Prostaglandin F1α (PGF1α) is a derivative of prostaglandin H1 (PGH1; Item No. 17015).1 It induces aggregation of isolated rabbit platelets (EC50 = 0.88 µM) and contraction of rabbit aortic strips (EC50 = 0.11 µM). 9,11-methane-epoxy PGF1α induces contraction of isolated guinea pig tracheas (EC50 = 3.4 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morita, A., Nishino, H., Hasegawa, K., et al. Biological activities of prostaglandin H1 analogs. Prostaglandins 18(4), 529-540 (1979).