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Muraglitazar

Item № 10007853
CAS № 331741-94-7
Purity ≥98%
product image
                (CAS 331741-94-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $280.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • BMS-298585

Muraglitazar is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ (EC50s = 0.32 and 0.11 μM, respectively).1 It is selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, estrogen receptor α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Muraglitazar (50 μM) reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes.2 It reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice when administered at a dose of 10 mg/kg per day.1 Muraglitazar (10 mg/kg per day) reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice.3 Muraglitazar also inhibits LPS-induced increases in nitric oxide (NO) production and IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) protein levels in J774 murine macrophages in a concentration-dependent manner.4 It inhibits carrageenan-induced paw edema in mice when administered at doses ranging from 12.5 to 50 mg/kg.

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Technical Information
Formal Name
N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-glycine
CAS Number
331741-94-7
Synonyms
  • BMS-298585
Molecular Formula
C29H28N2O7
Formula Weight
516.5
Purity
≥98%
Formulation
A crystalline powder
SMILES
O=C(OC1=CC=C(OC)C=C1)N(CC(O)=O)CC2=CC=C(C=C2)OCCC3=C(C)OC(C4=CC=CC=C4)=N3
InChI Code
InChI=1S/C29H28N2O7/c1-20-26(30-28(37-20)22-6-4-3-5-7-22)16-17-36-24-10-8-21(9-11-24)18-31(19-27(32)33)29(34)38-25-14-12-23(35-2)13-15-25/h3-15H,16-19H2,1-2H3,(H,32,33)
InChI Key
IRLWJILLXJGJTD-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Devasthale, P.V., Chen, S., Jeon, Y., et al. Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor α/γ dual agonist with efficacious glucose and lipid-lowering activities Journal of Medicinal Chemistry 48, 2248-2250 (2005).

2. Rogue, A., Anthérieu, S., Vluggens, A., et al. PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells Toxicol. Appl. Pharmacol. 276(1), 73-81 (2014).

3. Harrity, T., Farrelly, D., Tieman, A., et al. Muraglitazar, a novel dual (α/γ) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves β-cell function in db/db mice Diabetes 55(1), 240-248 (2006).

4. Paukkeri, E.-L., Leppänen, T., Lindholm, M., et al. Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models Arthritis Res. Ther. 15(2):R51, (2013).

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