A cyanotoxin and an inhibitor of PP1C, PP1γ, and PP2A
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Microcystin-RR

Item No. 10007868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-arginyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
CAS Number
111755-37-4
Synonyms
  • Cyanoginosin-RR
  • MC-RR
Molecular Formula
C49H75N13O12
Formula Weight
1038.2
Purity
≥95%
Formulation
A clear film
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol:Water: SolubleMethanol: Soluble
SMILES
CC(/C=C/[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](C)[C@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC1=O)=O)=O)=O)[C@H](C)C(N[C@@H](C(O)=O)CCC(N(C)C(C(N[C@@H]1C)=O)=C)=O)=O)=C\[C@@H]([C@H](CC2=CC=CC=C2)OC)C
InChi Code
InChI=1S/C49H75N13O12/c1-26(24-27(2)37(74-8)25-32-14-10-9-11-15-32)18-19-33-28(3)40(64)60-36(46(70)71)20-21-38(63)62(7)31(6)43(67)56-30(5)42(66)59-35(17-13-23-55-49(52)53)45(69)61-39(47(72)73)29(4)41(65)58-34(44(68)57-33)16-12-22-54-48(50)51/h9-11,14
InChi Key
NSQDNLWVBVLGHE-SINYXRRLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Microcystin-RR is a cyanotoxin and an inhibitor of protein phosphatase 1C (PP1C), PP1γ, and PP2A (Kis = 0.15, 0.24, and 0.018 nM, respectively).1 Intratracheal administration of microcystin-RR (1,200 µg/kg) induces hepatic bleeding in mice. Microcystin-RR has been found in freshwater with cyanobacterial blooms.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, E., Takai, A., Kondo, F., et al. Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 40(7), 1017-1025 (2002).

    2. Romera-García, E., Helmus, R., Ballesteros-Gómez, A., et al. Multi-class determination of intracellular and extracellular cyanotoxins in freshwater samples by ultra-high performance liquid chromatography coupled to high resolution mass spectrometry. Chemosphere 274, 129770 (2021).