An internal standard for the quantification of 14(15)-DiHET
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Unlabeled Version(s)
51651(±)14(15)-DiHET
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(±)14(15)-DiHET-d11

Item No. 10008040

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)14,15-dihydroxy-5Z,8Z,11Z-eicosatrienoic-16,16,17,17,18,18,19,19,20,20,20-d11 acid
Synonyms
  • (±)14,15-DiHETrE-d11
Molecular Formula
C20H23D11O4
Formula Weight
349.6
Purity
≥99% deuterated forms (d1-d11)
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
O[C@@H]([C@H](O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C/C=C\C/C=C\C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H34O4/c1-2-3-12-15-18(21)19(22)16-13-10-8-6-4-5-7-9-11-14-17-20(23)24/h4,6-7,9-10,13,18-19,21-22H,2-3,5,8,11-12,14-17H2,1H3,(H,23,24)/b6-4-,9-7-,13-10-/t18-,19-/m1/s1/i1D3,2D2,3D2,12D2,15D2
InChi Key
SYAWGTIVOGUZMM-QNSDZNOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $201

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    50 µg

    $378

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    100 µg

    $712

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    Product Description

    (±)14,15-DiHET-d11 is intended for use as an internal standard for the quantification of 14(15)-DiHET by GC- or LC-MS. 14(R),15(R)-DiHET and 14(S),15(S)-DiHET are vicinal diols formed via enzymatic hydration of 14(15)-EET by cytosolic or soluble epoxide hydrolases.1,2 14(R),15(R)-DiHET is produced at a greater proportion than 14(S),15(S)-DiHET by cytosolic epoxide hydrolase.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zeldin, D.C., Kobayashi, J., Falck, J.R., et al. Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. The Journal of Biological Chemisty 268(9), 6402-6407 (1993).

    2. Zhang, G., Kodani, S., and Hammock, B.D. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog. Lipid Res. 53, 108-123 (2014).