A urinary metabolite of (±)14(15)-EET
Related Products
Labeled Version(s)
10008040(±)14(15)-DiHET-d11
Parent Compound(s)
50651(±)14(15)-EET
Technical Support & Resources

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(±)14(15)-DiHET

Item No. 51651

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)14,15-dihydroxy-5Z,8Z,11Z-eicosatrienoic acid
Synonyms
  • (±)14,15-DiHETrE
Molecular Formula
C20H34O4
Formula Weight
338.5
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 1 mg/ml
SMILES
CCCCC[C@@H](O)[C@H](O)C/C=C\C/C=C\C/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H34O4/c1-2-3-12-15-18(21)19(22)16-13-10-8-6-4-5-7-9-11-14-17-20(23)24/h4,6-7,9-10,13,18-19,21-22H,2-3,5,8,11-12,14-17H2,1H3,(H,23,24)/b6-4-,9-7-,13-10-/t18-,19-/m1/s1
InChi Key
SYAWGTIVOGUZMM-JHIAIUNDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 µg

    $116

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    50 µg

    $220

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    100 µg

    $416

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    250 µg

    $867

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    Product Description

    (±)14(15)-DiHET is the urinary metabolite of (±)14(15)-EET (Item No. 50651) which has been documented by GC-MS to be elevated in pregnancy-induced hypertension.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Catella, F., Lawson, J.A., Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc. Natl. Acad. Sci. USA 87(15), 5893-5897 (1990).

    Product Citations

    Bracken, O.V., Jalali, P., Glanville, J.R.W., et al. Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humans. Nat. Commun. 17(1), 431 (2026).

    Pang, Y., Liu, X., Zhao, C., et al. LC-MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products. Free Radic. Biol. Med. 193(Pt 1), 363-372 (2022).

    Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018).

    Ding, Y., Frömel, T., Popp, R., et al. The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the Gs protein. J. Pharmacol. Exp. Ther. 350(1), 14-21 (2014).

    Morisseau, C., and Hammock, B.D. Measurement of soluble epoxide hydrolase (sEH) activity. Curr. Protoc. Toxicol. 4.23.2(Suppl. 33), (2007).