A fluorescent substrate of the 20S proteasome and calpain
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Suc-Leu-Leu-Val-Tyr-AMC

Item No. 10008119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-tyrosinamide
CAS Number
94367-21-2
Synonyms
  • Suc-LLVY-AMC
Molecular Formula
C40H53N5O10
Formula Weight
763.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
330 nm
SMILES
CC(C1=CC=C(C=C1O2)NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)C(C)C)=O)=O)=CC2=O
InChi Code
InChI=1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)
InChi Key
UVFAEQZFLBGVRM-MSMWPWNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $38

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    5 mg

    $94

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    10 mg

    $147

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    Product Description

    Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains (excitation max: 360 nm; emission max: 460 nm).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Geier, E., Pfeifer, G., Wilm, M., et al. A giant protease with potential to substitute for some functions of the proteasome. Science 283(5404), 978-981 (1999).

    2. Sasaki, T., Kikuchi, T., Yumoto, N., et al. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. The Journal of Biological Chemisty 259(20), 12489-12494 (1984).

    Product Citations

    Yoon, M.J., Kang, Y.J., Lee, J.A., et al. Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin. Cell Death Dis. 5, e1112 (2014).