An analgesic and anticonvulsant
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Analytical Standard(s)
22910Gabapentin 37860Gabapentin (CRM) 41131Gabapentin (CRM)
Labeled Version(s)
18254Gabapentin-d4
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Gabapentin

Item No. 10008346

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(aminomethyl)-cyclohexaneacetic acid
CAS Number
60142-96-3
Synonyms
  • CI-945
Molecular Formula
C9H17NO2
Formula Weight
171.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NCC1(CCCCC1)CC(=O)O
InChi Code
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
InChi Key
UGJMXCAKCUNAIE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    10 mg

    $42

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    25 mg

    $97

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    50 mg

    $183

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    100 mg

    $322

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    Cayman Chemical
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    Product Description

    Gabapentin is an analgesic and anticonvulsant.1 It inhibits current-induced signal transmission and reduces glutamatergic excitatory postsynaptic potentials in isolated rat striatal neurons (EC50s = 320.4 and 96.8 µM, respectively). Gabapentin (100 or 300 µM) inhibits glutamate-induced membrane depolarization in isolated rat striatal neurons. It decreases mechanical and cold allodynia in rats when administered at a dose of 60 mg/kg.2 Gabapentin reduces plasma levels of Tnf-α and Il-1β, increases sciatic nerve levels of glutathione (GSH), and decreases sciatic nerve levels of malonaldehyde (MDA) in a rat model of neuropathic pain induced by vincristine (Item No. 11764). It decreases the number of seizures induced by maximal electroshock (MES) in rats (ED50 = 14.8 mg/kg).3 Formulations containing gabapentin have been used in the treatment of postherpetic neuralgia and partial-onset seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Calabresi, P., Centonze, D., Marfia, G.A., et al. An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. Br. J. Pharmacol. 126(3), 689-696 (1999).

    2. Singh, G., Singh, A., Singh, P., et al. Bergapten ameliorates vincristine-induced peripheral neuropathy by inhibition of inflammatory cytokines and NFκB signaling. ACS Chem. Neurosci. 10(6), 3008-3017 (2019).

    3. Winkler, I., Blotnik, S., Shimshoni, J., et al. Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. Br. J. Pharmacol. 146, 198-208 (2005).