An internal standard for the quantification of gabapentin
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Unlabeled Version(s)
10008346Gabapentin
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Gabapentin-d4

Item No. 18254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(aminomethyl-d2)-cyclohexaneacetic-α,α-d2 acid
CAS Number
1185039-20-6
Molecular Formula
C9H13D4NO2
Formula Weight
175.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NC([2H])([2H])C1(C([2H])([2H])C(O)=O)CCCCC1
InChi Code
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)/i6D2,7D2
InChi Key
UGJMXCAKCUNAIE-KXGHAPEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $116

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    1 mg

    $220

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    Product Description

    Gabapentin-d4 is intended for use as an internal standard for the quantification of gabapentin (Item No. 10008346) by GC- or LC-MS. Gabapentin is a γ-aminobutyric acid (GABA) analogue that acts as an anticonvulsant.1,2,3 It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the GABA-metabolizing enzyme, GABA transaminase.4,5 Unlike GABA, which does not pass through the blood-brain barrier, gabapentin penetrates into the central nervous system and binds to the α2δ-type voltage-gated calcium channels. Formulations containing gabapentin have been used to treat neuropathic pain caused by complex regional pain syndrome type one, cancer, and HIV as well as to control dysesthesias in patients with multiple sclerosis.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van de Vusse, A.C., Stonmp-van de Berg, S.G.M., Kessels, A.H.F., et al. Randomised controlled trial of gabapentin in complex regional pain syndrome type I [ISRCTN84121379]. BMC Neurol. 4(13), (2004).

    2. Hahn, K., Arendt, G., Braun, J.S., et al. A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies. J. Neurol. 251(10), 1260-1266 (2004).

    3. Caraceni, A., Zecca, E., Bonezzi, C., et al. Gabapentin for neuropathic cancer pain: A randomized controlled trial from the gabapentin cancer pain study group. J. Clin. Oncol. 22(14), 2909-2917 (2004).

    4. Gee, N.S., Brown, J.P., Dissanayake, V.U.K., et al. The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel. The Journal of Biological Chemisty 271(10), 5768-5776 (1996).

    5. Goa, K.L., and Sorkin, E.M. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs 46(3), 409-427 (1993).